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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제10호
- 발행연도
- 2006.1
- 수록면
- 1,544 - 1,553 (10page)
이용수
초록· 키워드
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The halophilic enterobacteria, Enterobacteriacancerogenus, was isolated from the intestines of the fusiformfish (Trachurus japonicus) to yield a protein-like materialtermed PLM-f74. PLM-f74 was characterized by strongof 18.5g/ml) and elevated antioxidative capacities withlow toxicity. The PLM-f74 is a glycoprotein comprised ofsaccharides and amino acids. PLM-f74 inhibited cell adhesionthat non-activated U937 monocytic cell adhesion to HUVECsactivated with IL-1β by 78.0%, and the adherence of U937cells treated with the PLM-f74 and stimulated with IL-1β tounstimulated HUVECs decreased by 102%. When both celltypes were pretreated with PLM-f74, the adhesion of U937cells to IL-1β-stimulated HUVECs was completely suppresedby 121% at a concentration of 18.5g/ml. PLM-f74 blockedsignal pathways from VEGFR2, PI3K, β-catenin, and VE-cadherin to NF-kB, based on western bolt analysis. It alsoinhibited IL-1-stimulated HUVEC expresion of the adhesionmolecules, ICAM-1 by 40%, VCAM-1 by 60%, and E-selectin by 70% at the same concentration noted above. Newanti-angiogenic and anti-cell adhesion materials showing elevatedfrom these results.
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참고문헌 (25)
참고문헌 신청
Agarwal, A / 2005 / Role of oxidative stress in female reproduction / Reprod. Biol. Endocrinol. 14 : 1 ~ 36
Altavilla, D / 2005 / Lipid peroxidation inhibition by raxofelast improves angiogenesis and wound healing in experimental burn wounds / Shock 24 : 85 ~ 91
Augustin, H. G / 2005 / Angiogenesis in the female reproductive system / E.X.S. 94 : 35 ~ 52
Bates, D. O. / 2003 / The role of vascular endothelial growth factor in wound healing / Int. J. Low Extrem. Wounds 2 : 107 ~ 120
Beck, S. A / 1991 / Anticachetic and antitumor effect of EPA and its effect on protein turnover / Cancer Res. 51 : 6089 ~ 6095
Altavilla, D / 2005 / Lipid peroxidation inhibition by raxofelast improves angiogenesis and wound healing in experimental burn wounds / Shock 24 : 85 ~ 91
Augustin, H. G / 2005 / Angiogenesis in the female reproductive system / E.X.S. 94 : 35 ~ 52
Bates, D. O. / 2003 / The role of vascular endothelial growth factor in wound healing / Int. J. Low Extrem. Wounds 2 : 107 ~ 120
Beck, S. A / 1991 / Anticachetic and antitumor effect of EPA and its effect on protein turnover / Cancer Res. 51 : 6089 ~ 6095
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