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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 153 - 161 (9page)
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초록· 키워드
오류제보하기
Adhesion and migration of vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of atherosclerosis. These processes
involve the interaction of VSMCs with extracellular matrix proteins. Here, we investigated integrin
isoforms and signaling pathways mediating the adhesion and migration of VSMCs on β ig-h3, a
transforming growth factor (TGF)-β -inducible extra-cellular matrix protein that is elevated in ather-osclerotic plaques. Adhesion assays showed that the α v β 5 integrin is a functional receptor for the
adhesion of aortic VSMCs to β ig-h3. An YH18 motif containing amino acids between 563 and 580 of
β ig-h3 was an essential motif for the adhesion and growth of VSMCs. Interaction between the YH18 motif
and the α v β 5 integrin was responsible for the migration of VSMCs on β ig-h3. Inhibitors of pho-sphatidylinositide 3-kinase, extracellular signal-regulated kinase (ERK), and Src kinase reduced the adhesion and migration of VSMCs on β ig-h3. β ig-h3
triggered phosphorylation and activation of AKT, ERK, focal adhesion kinase, and paxillin mediating the adhesion and migration of VSMCs. Taken
together, these results suggest that β ig-h3 and α v β 5
integrin play a role in the adhesion and migration of
VSMCs during the pathogenesis of atherosclerosis.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Abedi H / 1995 / Differential effects of plate-let-derived growth factor BB on p125 focal adhesion kinase and paxillin tyrosine phosphorylation and on cell migration in rabbi
Bae JS / 2002 / Betaig-h3 supports keratinocyte adhesion, migration, and proliferation through al-pha3beta1 integrin 294 : 940 ~ 8
Batchelor WB / 1998 / The extracellular ma-trix in balloon arterial injury a novel target for restenosis prevention 41 : 35 ~ 49
Bobik A / 1999 / Distinct pat-terns of transforming growth factor-beta isoform and receptor expression in human atherosclerotic lesions Colocalization implicates TGF-beta in
Chiba S / 2002 / Development of atherosclerosis in osteopontin transgenic mice 16 : 11 ~ 7
Bae JS / 2002 / Betaig-h3 supports keratinocyte adhesion, migration, and proliferation through al-pha3beta1 integrin 294 : 940 ~ 8
Batchelor WB / 1998 / The extracellular ma-trix in balloon arterial injury a novel target for restenosis prevention 41 : 35 ~ 49
Bobik A / 1999 / Distinct pat-terns of transforming growth factor-beta isoform and receptor expression in human atherosclerotic lesions Colocalization implicates TGF-beta in
Chiba S / 2002 / Development of atherosclerosis in osteopontin transgenic mice 16 : 11 ~ 7
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