지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The process of atherosclerosis begins through secretion of inflammatory cytokine or
adhesion of leukocyte from damage in blood vessels and transmigration. This study was conducted
to investigate the effects of delphinidin chloride (DC) in the initial process of atherosclerosis on
the expression of ICAM-1 (Intracellular Adhesion Molecule-1) and VCAM-1 (Vascular Adhesion
Molecule-1) related to adhesion of leukocyte at the HUVEC (human umbilical vein endothelial
cell line. As a result, cell growth inhibition rate at 50 μM was respectively 4, 3 and 5% without cell
toxicity. As a result of morphological observation monocyte-endothelial cell adhesion assay and
optical microscope carried out to measure attachment of mononuclear cells to endothelial cells
induced by Tumor necrosis factor-alpha (TNF-α) at concentrations without cell toxicity, DC concentration-
dependently suppressed attachment. When effects on the expression of VCAM-1 and
ICAM-1, cell adhesion molecules induced from endothelial cells by TNF-α, were comparatively
analyzed using western blot analysis and RT-PCR methods, protein of VCAM-1 and ICAM-1 and
expression at the level of mRNA were concentration-dependently reduced. Taken together, the
results of this studies provide evidence that DC possess an anti-metastatic activity.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
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Barnes PJ / 1995 / Nitric oxide and asthema inflammation / Immunol. Today 16 : 128 ~ 130
Bereta M / 1992 / Low density lipoprotein inhibits accumulation of nitrites in murine brain endothelial cell cultures / Biochem. Biophys. Res. Commun. 186 : 315 ~ 320
Coleman JE / 2003 / Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo / Physiol. Genomics 12 : 221 ~ 228
DiDonato JA / 1997 / A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappa B / Nature. 388 : 548 ~ 554
Barnes PJ / 1995 / Nitric oxide and asthema inflammation / Immunol. Today 16 : 128 ~ 130
Bereta M / 1992 / Low density lipoprotein inhibits accumulation of nitrites in murine brain endothelial cell cultures / Biochem. Biophys. Res. Commun. 186 : 315 ~ 320
Coleman JE / 2003 / Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo / Physiol. Genomics 12 : 221 ~ 228
DiDonato JA / 1997 / A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappa B / Nature. 388 : 548 ~ 554
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