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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 663 - 672 (10page)
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초록· 키워드
오류제보하기
An extracelular matrix protein plays an important role in skin wound healing. In the present study, we en-gineered a recombinant protein encompasing the 9thand 10th type III domains of fibronectin, and 4th FAS1 do-main of βig-h3. This recombinant protein, in total, har-bors four known-cell adhesion motifs for integrins: Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) in 9th and 10th type III domains of fibronectin, respec-tively, and Glu-Pro-Asp-Ile-Met (EPDIM) and Try-His (YH) in 4th FAS1 domain of βig-h3, were designated to tetra-cell adhesion motifs (T-CAM). In vitro studies showed T-CAM supporting adhesion, migration and proliferation of different cell types including keratino-cytes and fibroblasts. In an animal model of full-thick-ness skin wound, T-CAM exhibited excellent wound th FAS1 domain of βig-h3 or 9th and 10th type III domains of fibronectin. Based on these results, T-CAM can be applied where enhancement of cell adhesion, migration and pro-liferation are desired, and it could be developed into novel wound healing drug.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
/ nature1984;309 / Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule : 30 ~ 3
Badylak AF / 2002 / The extracellular matrix as a scaffold for tissue reconstrction 13 : 377 ~ 383
Bae JS / 2002 / Betaig-h3 supports keratinocyte adhesion, migration, and proliferation through alpha3beta1 integrin 294 : 940 ~ 948
Bastiani MJ / / Expression of fasciclin I and I glycoproteins on subsets of axon pathways during neuronal development in the grasshopper : 745 ~ 55
Bennett K / / a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attach-ment in vitro and suppresses the growth of CHO cells
Badylak AF / 2002 / The extracellular matrix as a scaffold for tissue reconstrction 13 : 377 ~ 383
Bae JS / 2002 / Betaig-h3 supports keratinocyte adhesion, migration, and proliferation through alpha3beta1 integrin 294 : 940 ~ 948
Bastiani MJ / / Expression of fasciclin I and I glycoproteins on subsets of axon pathways during neuronal development in the grasshopper : 745 ~ 55
Bennett K / / a transforming growth factor-beta-responsive gene encoding a secreted protein that inhibits cell attach-ment in vitro and suppresses the growth of CHO cells
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