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Purpose: Lacunar stroke, in the context of small vessel disease, is a type of cerebral infarction caused by occlusion of a penetratingartery. Pulsatility index (PI) is an easily measurable parameter in Transcranial Doppler ultrasound (TCD) study. PI reflects distalcerebral vascular resistance and has been interpreted as a surrogate marker of small vessel disease. We hypothesized that an increasedPI, a marker of small vessel disease, might be associated with a larger infarct volume in acute lacunar stroke. Materials and Methods: This study included 64 patients with acute lacunar stroke who underwent TCD and brain MRI. We evaluatedthe association between the mean PI value of bilateral middle cerebral arteries and infarct volume on diffusion-weightedMRI using univariate and multivariate linear regression. Results: The mean infarct volume and PI were 482.18±406.40 mm3 and 0.86±0.18, respectively. On univariate linear regression,there was a significant positive association between PI and infarct volume (p=0.001). In the multivariate model, a single standarddeviation increase of PI (per 0.18) was associated with an increase of 139.05 mm3 in infarct volume (95% confidence interval, 21.25to 256.85; p=0.022). Conclusion: We demonstrated that PI was an independent determinant of infarct volume in acute lacunar stroke. The PI valuemeasured in acute stroke may be a surrogate marker of the extent of ischemic injury.

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