지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 187 - 195 (9page)
이용수
초록· 키워드
오류제보하기
Reparative dentine formation requires newly differentiated
odontoblast-like cells. Therefore, identification of the
molecule that stimulates the odontogenic differentiation of
precursor cells in the tooth pulp will be helpful for the
development of strategies to repair damaged pulp. In this
study, we examined the effect of N-acetylcysteine (NAC) on
the odontogenic differentiation of MDPC-23 cells, a mouse
odontoblast-like cell line derived from dental papilla, and
primary cultured rat dental papilla cells (RDPCs). NAC (1-
30 mM) suppressed production of reactive oxygen species in
MDPC-23 cells in a dose-dependent manner. Although 5 to
20 mM NAC did not alter MDPC-23 cell proliferation, 1 or
30 mM NAC significantly inhibited it. NAC enhanced
mineralized nodule formation and the expression of several
odontoblast differentiation-associated genes in both RDPCs
and MDPC-23. This NAC stimulatory effect was significant,
even at concentrations lower than 1 mM. However, NAC
did not stimulate expression of bone morphogenetic
protein-2, -4, or -7, which are known to enhance odontogenic
differentiation. Since reactive oxygen species are
also involved in the pulp toxicity of resin-based restorative
materials, these results suggest that NAC may be a promising
candidate for supplementation of dental restorative
materials in order to enhance reparative dentine formation.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Aruoma OI / 1989 / The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid / Free Radical Biology
Chen S / 2008 / Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signaling / Journal of Biological Chemist
Cox CF / 1996 / Tunnel defects in dentin bridges: their formation following direct pulp capping / OPERATIVE DENTISTRY 21 : 4 ~ 11
Decup F / 2000 / Bone sialoprotein-induced reparative dentinogenesis in the pulp of rat's molar. / Clinical oral investigations 4 : 110 ~ 119
Goldberg M / 2001 / Application of bioactive molecules in pulp-capping situations / Advances in dental research 15 : 91 ~ 95
Chen S / 2008 / Bone morphogenetic protein 2 mediates dentin sialophosphoprotein expression and odontoblast differentiation via NF-Y signaling / Journal of Biological Chemist
Cox CF / 1996 / Tunnel defects in dentin bridges: their formation following direct pulp capping / OPERATIVE DENTISTRY 21 : 4 ~ 11
Decup F / 2000 / Bone sialoprotein-induced reparative dentinogenesis in the pulp of rat's molar. / Clinical oral investigations 4 : 110 ~ 119
Goldberg M / 2001 / Application of bioactive molecules in pulp-capping situations / Advances in dental research 15 : 91 ~ 95
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Chitosan on the Differentiation of MDPC-23 Cells
International Journal of Oral Biology
2010 .01
-
Effect of Resveratrol on Cell Differentiation and Mineralization in Cultured Odontoblasts
International Journal of Oral Biology
2018 .01
-
The Beneficial Effect of Korean Red Ginseng on Rat Bladder Contractility and Oxidant Damage Following Ischemia/Reperfusion
International Neurourology Journal
2009 .01
-
Effect of Metformin on Cell Growth and Differentiation in Cultured Odontoblasts
International Journal of Oral Biology
2017 .01
-
MicroRNA Analysis during Cultured Odontoblast Differentiation
International Journal of Oral Biology
2012 .01
-
A Single-Center, Retrospective Study of Bevacizumab-Containing Neoadjuvant Chemotherapy followed by Interval Debulking Surgery for Ovarian Cancer
Yonsei Medical Journal
2020 .01
-
2-Nonadecanone Alleviates Depression through Inflammation Relief in SD Rat
대한의생명과학회지
2018 .09
-
MicroRNA-27 Promotes Odontoblast Differentiation via Wnt1 Signaling
International Journal of Oral Biology
2015 .01
-
Mouse Melanoma Cell Migration is Dependent on Production of Reactive Oxygen Species under Normoxia Condition
Biomolecules & Therapeutics(구 응용약물학회지)
2012 .01
-
The Role of Autonomous Wntless in Odontoblastic Differentiation of Mouse Dental Pulp Cells
Journal of Korean Dental Science
2016 .06
-
Impact of Molecular Subtype Conversion of Breast Cancers after Neoadjuvant Chemotherapy on Clinical Outcome
Cancer Research and Treatment
2016 .01
-
N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic Review
Clinical Psychopharmacology and Neuroscience
2015 .01
-
성견에 식립된 sandblasted and large-grit and acid-etched 임플란트에서 N-acetyl cysteine(NAC)의 탑재가 주위 골형성에 미치는 영향에 대한 선행연구
대한치과보철학회지
2020 .01
-
NAC이 포함된 PMMA계 골시멘트의 잔유 단량체가 세포독성에 미치는 영향과 HPLC를 이용한 화학적 분석
대한치과재료학회 학술대회
2013 .04
-
신기능 저하 환자의 조영제 신독성 예방을 위한 N-acetylcysteine 복용과 수액요법의 비교
대한내과학회지
2007 .01
-
Biological Effects of Light-Emitting Diodes Curing Unit on MDPC-23 Cells and Lipopolysaccharide Stimulated MDPC-23 Cells
치위생과학회지
2019 .01
-
THE ADHESION OF ODONTOBLAST TO TYPE I COLLAGEN
대한소아치과학회지
2010 .01
-
진행된 상피성 난소암 환자에서 신보조항암화학요법의 의의
Obstetrics & Gynecology Science
2007 .01
-
Antinociceptive and anti-inflammatory effects of N-acetylcysteine and verapamil in Wistar rats
The Korean Journal of Pain
2019 .01
-
The Protective Effects of N-Acetyl-L-cysteine on Cadmium-induced Cell Apoptosis in Rat Testis
대한의생명과학회지
2019 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0