메뉴 건너뛰기
Library Notice
Institutional Access
If you certify, you can access the articles for free.
Check out your institutions.
ex)Hankuk University, Nuri Motors
Log in Register Help KOR
Subject
Humanities
General Humanities History Philosophy Religious Studies Linguistics and Literature Other Humanities
Social science
General Social Science Business Management Tourism Education Military Science Library and Information Science Law Sociology Journalism and Media Studies Psychological Science Political Science and Diplomacy Geography Public Administration Economics International Trade Anthropology Other Social Science
Natural science
General Natural Science Physics Biology Life Sciences Mathematics/Statistics Astronomy Earth Science Chemistry Other Natural Science
Engineering
General Engineering Architectural Engineering Mechanical Engineering Industrial Engineering Material/Energy Engineering Electrical and Electronic Engineering Marine and Ocean Engineering Chemical Engineering Computer Science Other Engineering
Medical science
General Medical Science Nursing Science Veterinary Pharmacy Traditional Korean Medicine Basic Medicine Clinical Medicine Other Medicine
Agriculture and Fishery
General Agriculture and Fishery Agriculture Fishery Science Food Science Forestry Animal Husbandry Marine Transportation Studies Other Agriculture and Fishery
Art and Kinesiology
General Arts Design Fine Arts Cosmetology Photography Music Fashion Kinesiology Performing Media Arts Other Arts and Kinesiology
Interdisciplinary Studies
Interdisciplinary Research Science and Technology Studies Brain and Cognitive Science Technology Policy Other Interdisciplinary Studies

KOR

The Protective Effects of N-Acetyl-L-cysteine on Cadmium-induced Cell Apoptosis in Rat Testis
Recommendations
Search
Questions

논문 기본 정보

Type
Academic journal
Author
Ji-Sun Kim (Medical University of South Carolina) Jaemog Soh (Chonnam National University)
Journal
The Korean Society For Biomedical Laboratory Sciences Biomedical Science Letters Vol.25 No.4 KCI Accredited Journals
Published
2019.12
Pages
417 - 425 (9page)

Usage

cover
📌
Topic
📖
Background
🔬
Method
🏆
Result
The Protective Effects of N-Acetyl-L-cysteine on Cadmium-induced Cell Apoptosis in Rat Testis
Ask AI
Recommendations
Search
Questions

Abstract· Keywords

Report Errors
Cadmium (Cd) generates reactive oxygen species (ROS), which in turn cause the apoptosis of various cell types including developing germ cells in rodent testis. Ascorbic acids (AA), one of the ROS scavengers, had been reported to protect against Cd-induced apoptosis. N-Acetyl-L-cysteine (NAC), another ROS scavenger, is known to remove ROS and alleviate the Cd-induced apoptosis in various cell types. In this study we tried to elucidate how NAC affected on Cd-induced cell apoptosis in rat testis. Rats were administered with NAC before and after Cd treatment and then testicular cell apoptosis was examined. NAC treatment resulted in the reduction of Cd-induced chromosomal DNA fragmentation in agarose gel electrophoresis. Terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) assay showed that treatment of NAC reduced the Cd-induced apoptosis of germ cells. The administration of NAC showed that the translocation of apoptosis inducing factor (AIF) from mitochondria to nucleus was prevented, which indicated that the mechanism of Cd-induced testicular apoptosis is mediated through the release of AIF in caspase-independent manner. Taken together, the NAC may remove Cd-induced ROS and protect ROS-induced cell apoptosis in rat testis.
#N-Acetyl-L-cysteine #Cadmium #Apoptosis #Testis #Rat

Contents

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

References (30)

Add References
Acharya UR / 2008 / Effect of vitamin C and E on spermatogenesis in mice exposed to cadmium / Reprod Toxicol 25:84~88 google schola Aldini G / 2018 / N-acetylcysteine as an antioxidant and disulphide breaking agent: the reason why / Free Radic Res 52:751~762 google schola Ates B / 2008 / Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcystein (NAC) / Free Radic Res 42:372~377 google schola Cox B / 2006 / Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics / Nat Protoc 1:1872~1878 google schola Cregan SP / 2004 / Role of AIF in caspasedependent and caspase-independent cell death / Oncogene 23:2785~2796 google schola

Recommendations

It is an article recommended by DBpia according to the article similarity. Check out the related articles!

Related Authors

Recently viewed articles

Meta-analysis of the Effects of Early Childhood Personality Education Programs Using Picture Books
kim hyun jeong, CHOI KYOUNG NAM2023.06
 ADMINISTRATIVE CULTURE IN CHINA(Ⅰ)
Sunghan ImInstitute of Social Science1985.12

Comments(0)

0

Write first comments.

UCI(KEPA) : I410-ECN-0101-2020-510-000240498