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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 91 - 97 (7page)
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초록· 키워드
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The effects of chitosan upon the experimentally induced differentiation of MDPC-23 cells, derived from mouse dental papilla cells, were investigated by RT-PCR, observations of cell morphology and Alizaline red-S staining. Chitosan was found to significantly increase and accelerate the expression of ALP mRNA but decrease the ColI transcript levels, as compared with the control, in a time-dependent manner during the differentiation of MDPC-23 cells. Chitosan also significantly downregulated ON mRNA expression and accelerated mineralization in differentiating MDPC-23 cells.
These results suggest that chitosan facilitates odontoblast differentiation and mineralization and may have potential clinical applications as a dentin regeneration material.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
About I / 2000 / Human dentin production in vitro / Exp Cell Res 258 : 33 ~ 41
Begue-Kirn C / 1994 / Comparative analysis of TGF beta s, BMPs, IGF1,msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced o
Bosshardt DD / 2004 / Hertwig's epithelial root sheath,enamel matrix proteins, and initiation of cementogenesis in porcine teeth / J Clin Periodontol 31 : 184 ~ 192
Chien HH / 1999 / Expression of TGF-beta isoforms and their receptors during mineralized nodule formation by rat periodontal ligament cells in vitro / J Periodontal Res 34 :
D'Souza RN / 1997 / Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo /
Begue-Kirn C / 1994 / Comparative analysis of TGF beta s, BMPs, IGF1,msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced o
Bosshardt DD / 2004 / Hertwig's epithelial root sheath,enamel matrix proteins, and initiation of cementogenesis in porcine teeth / J Clin Periodontol 31 : 184 ~ 192
Chien HH / 1999 / Expression of TGF-beta isoforms and their receptors during mineralized nodule formation by rat periodontal ligament cells in vitro / J Periodontal Res 34 :
D'Souza RN / 1997 / Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo /
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