지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 142 - 151 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: N-acetylcysteine (NAC) is a potent antioxidant, and a free radical scavenger. We investigated the possible effects of NAC after ischemia/reperfusion (I/R) of rat bladder.
Materials and Methods: I/R injury was induced by abdominal aorta clamping and ischemia for 60minutes, followed by 120minutes reperfusion. Twenty rats were divided into four groups: sham operation + saline group (S+S), sham operation + NAC group (S+NAC), I/R + saline group (I/R+S), I/R + NAC group (I/R+NAC). Blood levels of reactive oxygen species (ROS) were determined using the free oxygen radical tests (FORT). Superoxide generation was measured based on lucigenin-enhanced chemiluminescence. The level of malondialdehyde (MDA) was analyzed in order to measure lipid peroxidation.
Results: In I/R+S group, the isometric contractile responses to carbachol were significant lower than other groups and were reversed by the pretreatment with NAC. The level of FORT and MDA showed a marked increase in I/R+S group compared with S+S group. NADPH-stimulated superoxide production was also significantly increased. I/R+NAC decreased these parameters compared with I/R+S group.
Conclusion: Our results suggest that treatment with NAC reversed the low contractile responses of rat bladder and prevented oxidative stress following I/R.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Aikawa K / 2003 / Effect of age on hydrogen peroxide mediated contraction damage in the male rat bladder / J Urol 170 : 2082 ~ 2085
Bratslavsky G / 1999 / Effects of in vivo ischemia on contractile responses of rabbit bladder to field stimulation, carbachol, ATP and KCl / Pharmacol 59 : 221 ~ 226
Bratslavsky G / 2003 / Reperfusion injury of the rat bladder is worse than ischemia / J Urol 170 : 2086 ~ 2090
Carpenter FG / 1983 / Impairment and restoration of rat urinary bladder responsiveness following distension / Am J Physiol 244 : 106 ~ 113
Cassarino DS / 1999 / An evaluation of the role of mitochondria inneurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses,
Bratslavsky G / 1999 / Effects of in vivo ischemia on contractile responses of rabbit bladder to field stimulation, carbachol, ATP and KCl / Pharmacol 59 : 221 ~ 226
Bratslavsky G / 2003 / Reperfusion injury of the rat bladder is worse than ischemia / J Urol 170 : 2086 ~ 2090
Carpenter FG / 1983 / Impairment and restoration of rat urinary bladder responsiveness following distension / Am J Physiol 244 : 106 ~ 113
Cassarino DS / 1999 / An evaluation of the role of mitochondria inneurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses,
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Single-Center, Retrospective Study of Bevacizumab-Containing Neoadjuvant Chemotherapy followed by Interval Debulking Surgery for Ovarian Cancer
Yonsei Medical Journal
2020 .01
-
2-Nonadecanone Alleviates Depression through Inflammation Relief in SD Rat
대한의생명과학회지
2018 .09
-
Stimulatory Effect of N-acetylcysteine on Odontoblastic Differentiation
International Journal of Oral Biology
2008 .01
-
Impact of Molecular Subtype Conversion of Breast Cancers after Neoadjuvant Chemotherapy on Clinical Outcome
Cancer Research and Treatment
2016 .01
-
Antinociceptive and anti-inflammatory effects of N-acetylcysteine and verapamil in Wistar rats
The Korean Journal of Pain
2019 .01
-
N-Acetyl Cysteine in the Treatment of Obsessive Compulsive and Related Disorders: A Systematic Review
Clinical Psychopharmacology and Neuroscience
2015 .01
-
신기능 저하 환자의 조영제 신독성 예방을 위한 N-acetylcysteine 복용과 수액요법의 비교
대한내과학회지
2007 .01
-
NAC이 포함된 PMMA계 골시멘트의 잔유 단량체가 세포독성에 미치는 영향과 HPLC를 이용한 화학적 분석
대한치과재료학회 학술대회
2013 .04
-
성견에 식립된 sandblasted and large-grit and acid-etched 임플란트에서 N-acetyl cysteine(NAC)의 탑재가 주위 골형성에 미치는 영향에 대한 선행연구
대한치과보철학회지
2020 .01
-
진행된 상피성 난소암 환자에서 신보조항암화학요법의 의의
Obstetrics & Gynecology Science
2007 .01
-
The Protective Effects of N-Acetyl-L-cysteine on Cadmium-induced Cell Apoptosis in Rat Testis
대한의생명과학회지
2019 .12
-
The Role of Oxygen Free Radicals and Phospholipase $A_2$ in Ischemia-reperfusion Injury to the Liver
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1995 .01
-
Involvement of Cortical Damage in the Ischemia/Reperfusion-Induced Memory Impairment of Wistar Rats
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2000 .01
-
온열적용이 대퇴사두근의 허혈-재관류 후 SOD 발현에 미치는 영향
대한물리치료학회지(JKPT)
2003 .01
-
The Effect of High Dose Melatonin on Cardiac Ischemia- reperfusion Injury
Yonsei Medical Journal
2008 .01
-
N-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis
Gut and Liver
2013 .01
-
백서 신경에서 관찰한 허혈-재관류 손상 후 양상과 회복
Annals of Rehabilitation Medicine
2003 .01
-
The Effect of Post-Treatment N-Acetylcysteine in LPS-Induced Acute Lung Injury of Rats
Tuberculosis and Respiratory Diseases
2012 .01
-
중탄산염 수액요법과 N-acetylcysteine의 조영제 신독성 예방효과
대한내과학회지
2011 .01
-
Acute hepatic injury following ischemia and reperfusion in rats
한국응용약물학회 춘계학술발표논문집
1994 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0