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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 39 - 45 (7page)
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Metformin (1,1-dimethylbiguanide hydrochloride), derived from French lilac (Galega officinalis), is a first-line anti-diabetic drug prescribed for patients with type 2 diabetes.
However, the role of metformin in odontoblastic cell differentiation is still unclear. This study therefore undertook to examine the effect of metformin on regulating odontoblast differentiation in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. As compared to controls, metformin significantly accelerated the mineralization, significantly increased and accelerated the expressions of ALP and Col I mRNAs, and significantly increased the accelerated expressions of DSPP and DMP-1 mRNAs, during differentiation of MDPC-23 cells. There was no alteration in cell proliferation of MDPC-23 cells, on exposure to metformin. These results suggest that the effect of metformin on MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells, facilitates the odontoblast differentiation and mineralization, without altering the cell proliferation.
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참고문헌 (26)
참고문헌 신청
김지원 / 2015 / Apoptotic Activity of Curcumin and EF-24 in HTB-41 Human Salivary Gland Epidermoid Carcinoma Cells / International Journal of Oral Biology 40(2):63~69
Qimei Gong / 2012 / Alteration of MicroRNA Expression of Human Dental Pulp Cells during Odontogenic Differentiation / Journal of Endodontics 38(10):1348~1354
Jae-Sung Kim / 2014 / Downregulation of adenomatous polyposis coli by microRNA-663 promotes odontogenic differentiation through activation of Wnt/beta-catenin signaling / Biochemical and Biophysical Research Communications 446(4):894~900
Amber Yasmeen / 2011 / Induction of apoptosis by metformin in epithelial ovarian cancer: Involvement of the Bcl-2 family proteins / Gynecologic Oncology 121 (3) : 492 ~ 498
D. Soranna / 2012 / Cancer Risk Associated with Use of Metformin and Sulfonylurea in Type 2 Diabetes: A Meta-Analysis / The Oncologist 17 (6) : 813 ~ 822
Qimei Gong / 2012 / Alteration of MicroRNA Expression of Human Dental Pulp Cells during Odontogenic Differentiation / Journal of Endodontics 38(10):1348~1354
Jae-Sung Kim / 2014 / Downregulation of adenomatous polyposis coli by microRNA-663 promotes odontogenic differentiation through activation of Wnt/beta-catenin signaling / Biochemical and Biophysical Research Communications 446(4):894~900
Amber Yasmeen / 2011 / Induction of apoptosis by metformin in epithelial ovarian cancer: Involvement of the Bcl-2 family proteins / Gynecologic Oncology 121 (3) : 492 ~ 498
D. Soranna / 2012 / Cancer Risk Associated with Use of Metformin and Sulfonylurea in Type 2 Diabetes: A Meta-Analysis / The Oncologist 17 (6) : 813 ~ 822
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