지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 308 - 316 (9page)
이용수
초록· 키워드
오류제보하기
Odontoblasts are anchorage dependent cells adhering to a substrate via cell adhesive molecules. Receptor ligands such as integrins bind to these proteins and are known to function as signal transduction molecules in a series of critical recognition events of cell-substratum. The aim of this study is to examine the interaction of odontoblast (MDPC-23 cell) with type I Col and the effect of TGF-β1 and TNF-αon the expression of cell adhesion molecules.
In this study, MDPC-23 cells adhered to type I Col dose-dependently. Immunofluorescence data demonstrated that integrin α1, α2 and CD44 were expressed on cell surface, and FAK and paxillin were localized in focal adhesion plaques in MDPC-23 cells adhesion to Col. Cytokine TGF-β1 increased the adhesion of MDPC-23 cells to Col and the expression level of integrin α1, α2 and chondroitin sulfate on MDPC-23 cells. RT-PCR data demonstrated that cytokine TGF-β1 increased the amount of integrin α1 mRNA in MDPC-23 cells.
Therefore, MDPC-23 cells adhere to collagen type I Col and expressed a complex pattern of integrins and proteoglycans,including α1, α2, chondroitin sulfate and CD44 detected by immunoblotting and immunofluorescence assay. TGF-β1 treatment enhanced the expression of adhesion molecules such as integrin α1, α2 and chondroitin sulfate.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bauvois B / 1992 / IFNgamma and transforming growth factor-beta 1 differently regulate fibronectin and laminin receptors of human differentiating monocytic cells / J Immunol
Boudreau NJ / 1999 / Extracellular matrix and integrin signalling: the shape of things to come / Biochem J 339 : 481 ~ 488
Cato′n J / 2009 / Current knowledge of tooth development: patterning and mineralization of the murine dentition / J Anat 214 : 502 ~ 515
Cichy J / 2003 / The liberation of CD44 / J Cell Biol 161 : 839 ~ 943
Claudino M / 2010 / Downregulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin
Boudreau NJ / 1999 / Extracellular matrix and integrin signalling: the shape of things to come / Biochem J 339 : 481 ~ 488
Cato′n J / 2009 / Current knowledge of tooth development: patterning and mineralization of the murine dentition / J Anat 214 : 502 ~ 515
Cichy J / 2003 / The liberation of CD44 / J Cell Biol 161 : 839 ~ 943
Claudino M / 2010 / Downregulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Effects of Chitosan on the Differentiation of MDPC-23 Cells
International Journal of Oral Biology
2010 .01
-
Effect of Resveratrol on Cell Differentiation and Mineralization in Cultured Odontoblasts
International Journal of Oral Biology
2018 .01
-
MicroRNA Analysis during Cultured Odontoblast Differentiation
International Journal of Oral Biology
2012 .01
-
Biological Effects of Light-Emitting Diodes Curing Unit on MDPC-23 Cells and Lipopolysaccharide Stimulated MDPC-23 Cells
치위생과학회지
2019 .01
-
Nuclear factor I-C 과발현과 발현억제가 MDPC-23 상아모세포주의 상아질 기질유전자 발현에 미치는 영향
치위생과학회지
2009 .01
-
Effect of Metformin on Cell Growth and Differentiation in Cultured Odontoblasts
International Journal of Oral Biology
2017 .01
-
뇌경색에서 부착분자를 이용한 치료응용
대한뇌졸중학회지
1999 .01
-
RNA interference를 이용한 OD314 유전자의 발현 억제가 상아질모세포 전구세포에 미치는 영향
해부·생물인류학
2004 .06
-
코엔자임 Q10 처리에 따른 TEGDMA에 의해 유발된 치아세포 사멸 억제 효과
한국치위생학회지
2014 .01
-
Melatonin이 MDPC-23 세포의 분화에 미치는 영향
해부·생물인류학
2007 .06
-
Stimulatory Effect of N-acetylcysteine on Odontoblastic Differentiation
International Journal of Oral Biology
2008 .01
-
단핵구 기능 수행에서의 $CD29({\beta}1-integrins)$ 조절 역할
약학회지
2008 .01
-
MicroRNA-27 Promotes Odontoblast Differentiation via Wnt1 Signaling
International Journal of Oral Biology
2015 .01
-
BAY11-7082에 의한 U937 세포의 CD29-매개성 세포간 유착과정 조절 효과
약학회지
2008 .01
-
CD98 Activation Increases the Invasion of Human Breast Carcinoma MCF-7 Cells
해부·생물인류학
2007 .09
-
Hyaluronic Acid에 대한 사람 뼈육종의 부착에 있어서 CD44의 역할
해부·생물인류학
2001 .12
-
Low-Intensity Pulsed Ultrasound Promotes Healing with Increases Collagen Deposition and Collagen mRNA Expression in Skin Wound of Rat
대한물리의학회지
2013 .01
-
태아 간 적혈구형성에서 형질전환성장인자의 발현
해부·생물인류학
1999 .06
-
Effect of Soy Isoflavones on the Expression of TGF-β1 and Its Receptors in Cultured Human Breast Cancer Cell Lines
대한의생명과학회지
2005 .06
-
흰쥐 상아질모세포 분화과정에서 OD314의 역할
해부·생물인류학
2005 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0