지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The actin cytoskeleton plays fundamental roles in ciliogenesis and the actin depolymerizing factor destrin regulates actin dynamics by treadmilling actin filaments and increasing globular actin pools. However, the specific developmental roles of destrin in ciliogenesis have not been fully elucidated. Here, we investigated the function of destrin in ciliogenesis using Xenopus laevis and human retinal pigmented epithelial (hRPE1) cells. We discovered the loss of destrin increased the number of multiciliated cells in the Xenopus epithelium and impeded cilia motility. Additionally, destrin depletion remarkably reduced the length of primary cilia in the Xenopus neural tube and hRPE1 cells by affecting actin dynamics. Immunofluorescence using markers of ciliary components indicated that destrin controls the directionality and polarity of basal bodies and axonemal elongation by modulating actin dynamics, independent of basal body docking. In conclusion, destrin plays a significant role during vertebrate ciliogenesis regulating both primary and multicilia development. Our data suggest new insights for understanding the roles of actin dynamics in cilia development.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Actin depolymerizing factor destrin governs cell migration in neural development during Xenopus embryogenesis
Molecules and Cells
2024 .01
-
Karyopherins Involved in the Nuclear Actin Transport
한국미생물학회 학술대회논문집
2016 .04
-
Exploring the Actin Dynamic Pathway Hijacked by HIV-1 Infection
한국미생물학회 학술대회논문집
2019 .04
-
Diverse Effects of Small Molecule Inhibitors on Actin Cytoskeleton Dynamics in HIV-1 Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .06
-
Karyopherins and Nuclear actin transport
Biodesign
2015 .06
-
Abiotic Stress-Induced Actin- Depolymerizing Factor 3 From Deschampsia antarctica Enhanced Cold Tolerance When Constitutively Expressed in Rice
극지연구소 초록집
2022 .09
-
Actin Dysfunction Induces Cell Cycle Delay at G2/M with Sustained ERK and RSK Activation in IMR-90 Normal Human Fibroblasts
Molecules and Cells
2018 .03
-
Increased Primary Cilia in Idiopathic Pulmonary Fibrosis
Molecules and Cells
2018 .03
-
Ckb and Ybx2 interact with Ribc2 and are necessary for the ciliary beating of multi-cilia
Genes & Genomics
2023 .02
-
The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate
Molecules and Cells
2017 .04
-
Time-Lapse Live-Cell Imaging Reveals Dual Function of Oseg4, Drosophila WDR35, in Ciliary Protein Trafficking
Molecules and Cells
2018 .07
-
The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium Disassembly
Molecules and Cells
2017 .06
-
Transport of Golgi-localized β-catenin p-S47 by KIF11 or KIFC3 induces primary ciliogenesis
Molecules and Cells
2024 .01
-
Mechanisms of Weight Control by Primary Cilia
Molecules and Cells
2022 .04
-
MS2 Labeling of Endogenous Beta-Actin mRNA Does Not Result in Stabilization of Degradation Intermediates
Molecules and Cells
2019 .01
-
WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation
Molecules and Cells
2020 .01
-
Targeted Base Editing via RNA-Guided Cytidine Deaminases in Xenopus laevis Embryos
Molecules and Cells
2017 .11
-
Development and Degeneration of Retinal Ganglion Cell Axons in Xenopus tropicalis
Molecules and Cells
2022 .11
-
Effects of thymosin β4-derived peptides on migration and invasion of ovarian cancer cells
Genes & Genomics
2021 .08
-
Intracellular Trafficking Modulation by Ginsenoside Rg3 Inhibits Brucella abortus Uptake and Intracellular Survival within RAW 264.7 Cells
Journal of Microbiology and Biotechnology
2017 .01
최근 본 자료
댓글(0)
0