WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation

JiSheng Hu; ShangJing Pi; MingRui Xiong; ZhongYing Liu; Xia Huang; Ran An; TongCun Zhang; BaiYin Yuan

추천

검색

자료유형: 학술저널

저자정보: JiSheng Hu (Wuhan University of Science and Technology) ShangJing Pi (Wuhan University of Science and Technology) MingRui Xiong (Wuhan University of Science and Technology) ZhongYing Liu (Wuhan University of Science and Technology) Xia Huang (Wuhan University of Science and Technology) Ran An (Wuhan University of Science and Technology) TongCun Zhang (Wuhan University of Science and Technology) BaiYin Yuan (Wuhan University of Science and Technology)

저널정보: 한국분자세포생물학회 Molecules and Cells Molecules and Cells 제43권 제8호

발행연도: 2020.1

수록면: 749 - 762 (14page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

The migration, dedifferentiation, and proliferation of vascular smooth muscle cells (VSMCs) are responsible for intimal hyperplasia, but the mechanism of this process has not been elucidated. WD repeat domain 1 (WDR1) promotes actin-depolymerizing factor (ADF)/cofilin-mediated depolymerization of actin filaments (F-actin). The role of WDR1 in neointima formation and progression is still unknown. A model of intimal thickening was constructed by ligating the left common carotid artery in Wdr1 deletion mice, and H&E staining showed that Wdr1 deficiency significantly inhibits neointima formation. We also report that STAT3 promotes the proliferation and migration of VSMCs by directly promoting WDR1 transcription. Mechanistically, we clarified that WDR1 promotes the proliferation and migration of VSMCs and neointima formation is regulated by the activation of the JAK2/STAT3/WDR1 axis.

#migration #neointima formation #proliferation #vascular smooth muscle cells #WD repeat domain 1

참고문헌 (48)

참고문헌 신청

Allahverdian, S. / 2018 / Smooth muscle cell fate and plasticity in atherosclerosis / Cardiovasc. Res 114:540~550

Bamburg, J. R / 1999 / Proteins of the ADF/cofilin family : essential regulators of actin dynamics / Annu. Rev. Cell Dev. Biol 15:185~230

Bravo-Cordero, J. J. / 2013 / Functions of cofilin in cell locomotion and invasion / Nat. Rev. Mol. Cell Biol 14:405~415

Cervero, P. / 2012 / Proteomic analysis of podosome fractions from macrophages reveals similarities to spreading initiation centres / Eur. J. Cell Biol 91:908~922

Chang, Q. / 2013 / The IL-6/JAK/Stat3 feedforward loop drives tumorigenesis and metastasis / Neoplasia 15:848~862

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!