지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.1
- 수록면
- 1 - 14 (14page)
- DOI
- 10.1016/j.mocell.2024.100142
이용수
초록· 키워드
오류제보하기
Primary cilium is an important hub for cell signaling and dysregulation of primary cilia assembly and disassembly is associated with the development of cancer and chemotherapeutic drug resistance, as well as the genetic disorders collectively known as ciliopathy. β-catenin plays a major role in canonical Wnt signaling; however, its association with primary cilia has only recently been highlighted in reports of β-catenin-mediated primary ciliogenesis. In this study, we found that β-catenin p-S47 was localized to the Golgi apparatus and the nucleus, and the amount of β-catenin p-S47 at these locations was significantly higher during primary ciliogenesis compared with asynchronous cell growth conditions. In addition, the novel β-catenin-binding motor proteins KIF11 and KIFC3 were shown to have a lower binding affinity in β-catenin S47A than in β-catenin wild-type. Knockdown of KIF11 or KIFC3 resulted in primary cilia deficiency and increased β-catenin p-S47 levels in the Golgi apparatus and were accompanied by a decrease in β-catenin p-S47 at the centrosome. The accumulation of β-catenin p-S47 in the nucleus was increased during primary ciliogenesis along with β-catenin-dependent transcriptional activity. The collective findings indicate the existence of a novel mechanism of primary ciliogenesis involving KIF11-/KIFC3-associated β-catenin p-S47 in the Golgi apparatus and β-catenin p-S47 transcriptional activity in the nucleus. This study revealed a new mechanism for the study of ciliopathies, cancer, and chemotherapeutic drug resistance caused by primary ciliogenesis dysregulation and provides new targets for drug development to treat these diseases.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comprehensive Review of Golgi Staining Methods for Nervous Tissue
한국현미경학회지
2017 .01
-
Golgi Stress Response: New Insights into the Pathogenesis and Therapeutic Targets of Human Diseases
Molecules and Cells
2023 .04
-
Effects of δ-Catenin on APP by Its Interaction with Presenilin-1
Molecules and Cells
2019 .01
-
δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer
Molecules and Cells
2018 .03
-
홍만병초 분획물에 의한 HT-29대장암 세포의 Wnt/β-catenin 신호전달 조절
생명과학회지
2019 .08
-
Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway
Journal of Microbiology and Biotechnology
2021 .11
-
Mutation Hotspots in the β-catenin Gene : Lessons from Human Cancer Genome Databases
Molecules and Cells
2019 .01
-
Ginsenoside Rg4 enhances the inductive effects of human dermal papilla spheres on hair growth via the AKT/GSK-3β/β-catenin signaling pathway
Journal of Microbiology and Biotechnology
2021 .01
-
The Roles of the SNARE Protein Sed5 in Autophagy in Saccharomyces cerevisiae
Molecules and Cells
2017 .09
-
BK Channel Deficiency in Osteoblasts Reduces Bone Formation via the Wnt/β-Catenin Pathway
Molecules and Cells
2021 .08
-
Non-Polar Myxococcus fulvus KYC4048 Metabolites Exert Anti-Proliferative Effects via Inhibition of Wnt/β-Catenin Signaling in MCF-7 Breast Cancer Cells
Journal of Microbiology and Biotechnology
2021 .01
-
SDC4 Gene Silencing Favors Human Papillary Thyroid Carcinoma Cell Apoptosis and Inhibits Epithelial Mesenchymal Transition via Wnt/β-Catenin Pathway
Molecules and Cells
2018 .09
-
Liraglutide Inhibits the Apoptosis of MC3T3-E1 Cells Induced by Serum Deprivation through cAMP/PKA/β-Catenin and PI3K/AKT/GSK3β Signaling Pathways
Molecules and Cells
2018 .03
-
Strategies to Isolate Drug-resistant Strains and to Identify New Drug Resistance Mechanisms
한국미생물학회 학술대회논문집
2022 .10
-
Low Molecular Weight Collagen Peptide (LMWCP) Promotes Hair Growth by Activating the Wnt/GSK-3β/β-Catenin Signaling Pathway
Journal of Microbiology and Biotechnology
2024 .01
-
Interaction of Ras-GTPase-activating Protein SH3 Domain-binding Proteins 2, G3BP2, With the C-terminal Tail Region of KIF5A
생명과학회지
2017 .10
-
Interaction of CLIP-170, a Regulator of Microtubule Plus End Dynamics, with Kinesin 1 via KIF5s
생명과학회지
2017 .06
-
CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures
Molecules and Cells
2019 .01
-
The Heterotrimeric Kinesin-2 Family Member KIF3A Directly Binds to Creatine Kinase B
생명과학회지
2021 .03
-
Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Molecules and Cells
2020 .01
최근 본 자료
댓글(0)
0