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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 243 - 253 (11page)
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Eukaryotic cilia are organelles that project from the surface of cells to fulfill motility and sensory functions. In vertebrates, the functions of both motile and immotile cilia are critical for em-bryonic development and adult tissue homeostasis. Importantly, a multitude of human diseases is caused by abnormal cilia biogenesis and functions which rely on the com-partmentalization of the cilium and the maintenance of its protein composition. The transition zone (TZ) is a specialized ciliary domain present at the base of the cilium and is part of a gate that controls protein entry and exit from this organelle. The relevance of the TZ is highlighted by the fact that several of its components are coded by ciliopathy genes. Here we review recent developments in the study of TZ proteomes, the mapping of individual compo-nents to the TZ structure and the establishment of the TZ as a lipid gate.
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참고문헌 (85)
참고문헌 신청
Abdelhamed, Z. A. / 2015 / The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the noncanonical Wnt pathway / Dis. Model. Mech 8:527~541
Arts, H. H. / 2007 / Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome / Nat. Genet 39:882~888
Awata, J. / 2014 / NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone / J. Cell Sci 127:4714~4727
Bachmann-Gagescu, R. / 2011 / The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking / Hum. Mol. Genet 20:4041~4055
Bachmann-Gagescu, R. / 2015 / The ciliopathy protein CC2D2A associates with NINL and functions in RAB8-MICAL3-regulated vesicle trafficking / PLoS Genet 11:e1005575
Arts, H. H. / 2007 / Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome / Nat. Genet 39:882~888
Awata, J. / 2014 / NPHP4 controls ciliary trafficking of membrane proteins and large soluble proteins at the transition zone / J. Cell Sci 127:4714~4727
Bachmann-Gagescu, R. / 2011 / The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking / Hum. Mol. Genet 20:4041~4055
Bachmann-Gagescu, R. / 2015 / The ciliopathy protein CC2D2A associates with NINL and functions in RAB8-MICAL3-regulated vesicle trafficking / PLoS Genet 11:e1005575
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