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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 987 - 993 (7page)
- DOI
- 10.1007/s13258-021-01127-7
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초록· 키워드
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Background Thymosin β4 (Tβ4) is a highly conserved actin binding protein associated with the metastatic potential of tumor cells by stimulating cell migration. The role of Tβ4 and its derived fragment peptides in migration of ovarian cancer cells has not been studied.
Objective To analyze the efects of Tβ4 and its derived fragment peptides on ovarian cancer cell migration and invasion, we applied Tβ4 and three Tβ4-derived synthetic peptides to SKOV3 ovarian cancer cells.
Method The migration and invasion of SKOV3 cells treated with Tβ4(1?43), Tβ4(1?15), Tβ4(12?26), Tβ4(23?), and untreated control were analyzed by in vitro migration and invasion assay with transwell plate. Cell proliferation assay was conducted to identify the efect of Tβ4 and its derived peptide on SKOV3 cell proliferation. The expression of Tβ4 related proteins related with cell proliferation was analyzed by Western blot after treatment with Tβ4 and its derived peptides.
Results Cell migration and invasion were signifcantly increased in Tβ4 peptide-treated SKOV3 cells compared with untreated control. All three Tβ4-derived fragment peptides including those without an actin binding site signifcantly stimulated migration and invasion of SKOV3 cells. Tβ4 and its derived peptide signifcantly stimulated SKOV3 cell proliferation and up-regulated the expression of RACK-1 protein.
Conclusions The Tβ4 peptide and all of its derived fragment peptides including those without an actin binding motif stimulate migration and invasion of SKOV3 ovarian cancer cells. All peptides signifcantly increased RACK-1 expression and cell proliferation of SKOV3 cells. These results suggest that Tβ4 stimulates migration and invasion of SKOV3 cells by stimulation of cell proliferation through up-regulation of RACK-1 protein.
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참고문헌 (13)
참고문헌 신청
Cha HJ / 2003 / Role of thymosin beta4in tumor metastasis and angiogenesis / J Natl Cancer Inst 95:1674~1680
Chu Y / 2019 / Adipose-derived mesenchymal stem cells enhance ovarian cancer growth and metastasis by increasing thymosin beta 4X-linked expression / Stem Cells Int 2019:9037197
Crockford D / 2010 / Thymosin beta4 : structure, function, and biological properties supporting current and future clinical applications / Ann N Y Acad Sci 1194:179~189
Dan H / 2020 / RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF-kappaB pathway in oral squamous cell carcinoma / Mol Oncol 14:795~807
Fei L / 2017 / RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex / Oncotarget 8:40501~40513
Chu Y / 2019 / Adipose-derived mesenchymal stem cells enhance ovarian cancer growth and metastasis by increasing thymosin beta 4X-linked expression / Stem Cells Int 2019:9037197
Crockford D / 2010 / Thymosin beta4 : structure, function, and biological properties supporting current and future clinical applications / Ann N Y Acad Sci 1194:179~189
Dan H / 2020 / RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF-kappaB pathway in oral squamous cell carcinoma / Mol Oncol 14:795~807
Fei L / 2017 / RACK1 promotes lung cancer cell growth via an MCM7/RACK1/ Akt signaling complex / Oncotarget 8:40501~40513
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