지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.6
- 수록면
- 401 - 409 (9page)
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초록· 키워드
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The primary cilium is a non-motile microtubule-based organelle that protrudes from the surface of most human cells and works as a cellular antenna to accept extracellular signals. Primary cilia assemble from the basal body during the resting stage (G0 phase) and simultaneously disassemble with cell cycle re-entry. Defective control of assembly or disassembly causes diverse human diseases including ciliopathy and cancer. To identify the effective compounds for studying primary cilium disassembly, we have screened 297 natural compounds and identified 18 and 17 primary cilium assembly and disassembly inhibitors, respectively. Among them, the application of KY-0120, identified as Brefeldin A, disturbed Dvl2-Plk1-mediated cilium disassembly via repression of the interaction of CK1ε-Dvl2 and the expression of Plk1 mRNA. Therefore, our study may suggest useful compounds for studying the cellular mechanism of primary cilium disassembly to prevent ciliopathy and cancer.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Barr, F. A. / 2004 / Polo-like kinases and the orchestration of cell division / Nat. Rev. Mol. Cell Biol 5:429~440
Bryja, V. / 2007 / Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism / J. Cell Sci 120:586~595
Charles, J. F. / 1998 / The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae / Curr. Biol 8:497~507
Colanzi, A. / 2013 / Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS / Proc. Natl. Acad. Sci. USA 110:9794~9799
Goetz, S. C. / 2010 / The primary cilium: a signalling centre during vertebrate development / Nat. Rev. Genet 11:331~344
Bryja, V. / 2007 / Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism / J. Cell Sci 120:586~595
Charles, J. F. / 1998 / The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae / Curr. Biol 8:497~507
Colanzi, A. / 2013 / Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS / Proc. Natl. Acad. Sci. USA 110:9794~9799
Goetz, S. C. / 2010 / The primary cilium: a signalling centre during vertebrate development / Nat. Rev. Genet 11:331~344
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