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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Although compartmentalization of a eukaryotic cell into the nucleus and cytoplasm has benefits, it further necessitatestransport between the two compartments. Active transport between these two compartments requires metabolicenergy and transporter proteins. Nuclear transporter receptors belong to the karyopherin super family and aid in themovement of cargo into (importers) or out of the nucleus (exporters) or are bidirectional. Presence of actin in nucleusand its nuclear trafficking remains intriguing due to its lack of nuclear import or export signals. Despite the fact thatimportin-9 and exportin-6 have been linked to nuclear import and export of actin respectively, the mechanistic detailsabout actin-karyopherin interaction are not known yet. In this review, we compared the structural details of alreadyavailable karyopherins and provide the initial structural prediction for exportin-6. The WH2 domain from diverse actinbinding proteins display a similar architecture of N-terminal α helix followed by the LKKT(V) motif. A similar LKPS motifwas identified near helix 14A of exportin-6, which might be the binding site for actin. Based on these predictions, we havepostulated a mechanism of actin-karyopherin interaction.
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참고문헌 (64)
참고문헌 신청
Andrade, M. A. / 1995 / HEAT repeats in the Huntington's disease protein / Nat Genet 11:115~116
Arts, G. J. / 1998 / The role of exportin-t in selective nuclear export of mature tRNAs / Embo J 17:7430~7441
Baarlink, C. / 2013 / Nuclear actin network assembly by formins regulates the SRF coactivator MAL / Science 340:864~867
Bohnsack, M. T. / 2002 / Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm / Embo J 21:6205~6215
Bohnsack, M. T. / 2006 / A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes / Nat Cell Biol 8:257~263
Arts, G. J. / 1998 / The role of exportin-t in selective nuclear export of mature tRNAs / Embo J 17:7430~7441
Baarlink, C. / 2013 / Nuclear actin network assembly by formins regulates the SRF coactivator MAL / Science 340:864~867
Bohnsack, M. T. / 2002 / Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm / Embo J 21:6205~6215
Bohnsack, M. T. / 2006 / A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes / Nat Cell Biol 8:257~263
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