Antiamoebic activities of flavonoids against pathogenic free-living amoebae, Naegleria fowleri and Acanthamoeba species

Hương Giang Lê; Tuấn Cường Võ; Jung-Mi Kang; Thu Hằng Nguyễn; Buyng-Su Hwang; Young-Taek Oh; Byoung-Kuk Na

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자료유형: 학술저널

저자정보: Hương Giang Lê (Gyeongsang National University College of Medicine) Tuấn Cường Võ (Gyeongsang National University College of Medicine) Jung-Mi Kang (Gyeongsang National University College of Medicine) Thu Hằng Nguyễn (Gyeongsang National University College of Medicine) Buyng-Su Hwang (Nakdonggang National Institute of Biological Resources) Young-Taek Oh (Nakdonggang National Institute of Biological Resources) Byoung-Kuk Na (Gyeongsang National University College of Medicine)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases Parasites, Hosts and Diseases Vol.61 No.4

발행연도: 2023.11

수록면: 449 - 454 (6page)

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Free-living amoebae (FLA) rarely cause human infections but can invoke fatal infections in the central nervous system (CNS). No consensus treatment has been established for FLA infections of the CNS, emphasizing the urgent need to discover or develop safe and effective drugs. Flavonoids, natural compounds from plants and plant-derived products, are known to have antiprotozoan activities against several pathogenic protozoa parasites. The anti-FLA activity of flavonoids has also been proposed, while their antiamoebic activity for FLA needs to be emperically determined. We herein evaluated the antiamoebic activities of 18 flavonoids against Naegleria fowleri and Acanthamoeba species which included A. castellanii and A. polyphaga. These flavonoids showed different profiles of antiamoebic activity against N. fowleri and Acanthamoeba species. Demethoxycurcumin, kaempferol, resveratrol, and silybin (A+B) showed in vitro antiamoebic activity against both N. fowleri and Acanthamoeba species. Apigenin, costunolide, (‒)-epicatechin, (‒)-epigallocatechin, rosmarinic acid, and (‒)-trans-caryophyllene showed selective antiamoebic activity for Acanthamoeba species. Luteolin was more effective for N. fowleri. However, afzelin, berberine, (±)-catechin, chelerythrine, genistein, (+)-pinostrobin, and quercetin did not exhibit antiamoebic activity against the amoeba species. They neither showed selective antiamoebic activity with significant cytotoxicity to C6 glial cells. Our results provide a basis for the anti-FLA activity of flavonoids, which can be applied to develope alternative or supplemental therapeutic agents for FLA infections of the CNS.

#Naegleria fowleri #Acanthamoeba #flavonoids #antiamoebic activity

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