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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 501 - 505 (5page)
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초록· 키워드
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The pathogenic free-living amoeba Naegleria fowleri causes primary amoebic meningoencephalitis, a fatal infection, by penetrating the nasal mucosa and migrating to the brain via the olfactory nerves. N. fowleri can induce host cell death via lytic necrosis. Similar to phosphorylation, O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation (O-GlcNAcylation) is involved in various cell-signaling processes, including apoptosis and proliferation, with O-GlcNAc addition and removal regulated by O-GlcNAc transferase and O-GlcNAcase (OGA), respectively. However, the detailed mechanism of host cell death induced by N. fowleri is unknown. In this study, we investigated whether N. fowleri can induce the modulation of O-GlcNAcylated proteins during cell death in Jurkat T cells. Co-incubation with live N. fowleri trophozoites increased DNA fragmentation. In addition, incubation with N. fowleri induced a dramatic reduction in O-GlcNAcylated protein levels in 30 min. Moreover, pretreatment of Jurkat T cells with the OGA inhibitor PUGNAc prevented N. fowleri–induced O-deGlcNAcylation and DNA fragmentation. These results suggest that O-deGlcNAcylation is an important signaling process that occurs during Jurkat T cell death induced by N. fowleri.
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참고문헌 (14)
참고문헌 신청
Jahangeer M / 2020 / Naegleria fowleri:Sources of infection, pathophysiology, diagnosis, and managment; a review / Clin Exp Pharmacol Physiol 47:199~212
김종현 / 2008 / Contact-Independent Cell Death of Human Microglial Cells due to Pathogenic Naegleria fowleri Trophozoites / The Korean Journal of Parasitology 46(4):217~221
Kang SY / 2005 / Role of the Nfa1 protein in pathogenic Naegleria fowleri cocultured with CHO target cells / Clin Diagn Lab Immunol 12:873~876
Song KJ / 2011 / Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri / https://doi.org/10.1111/j.1365-3024.2011.01297.x 33:390~400
Vosseller K / 2002 / Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification / Curr Opin Chem Biol 6:851~857
김종현 / 2008 / Contact-Independent Cell Death of Human Microglial Cells due to Pathogenic Naegleria fowleri Trophozoites / The Korean Journal of Parasitology 46(4):217~221
Kang SY / 2005 / Role of the Nfa1 protein in pathogenic Naegleria fowleri cocultured with CHO target cells / Clin Diagn Lab Immunol 12:873~876
Song KJ / 2011 / Reactive oxygen species-dependent necroptosis in Jurkat T cells induced by pathogenic free-living Naegleria fowleri / https://doi.org/10.1111/j.1365-3024.2011.01297.x 33:390~400
Vosseller K / 2002 / Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification / Curr Opin Chem Biol 6:851~857
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