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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 169 - 175 (7page)
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초록· 키워드
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Naegleria fowleri, a pathogenic free-living amoeba, leads to a fatal infection known as primary amebic meningoencephalitis (PAM) in human and animals. PAM is an acute, fulminant, necrotizing, and hemor-rhagic disease that leads to death in approximately seven days. In this study, we investigate the cytotox-icity of target cells and the secreted molecules of N. fowleri under the non-contact condition. The target cell (U87MG cell) treated with N. fowleri lysates showed no morphological changes and no cytotoxicity. By contrast, the U87MG cells co-cultured with N. fowleri trophozoites under the non-contact condition induced morphological changes and reduction in number. When U87MG cells were co-cultured with N. fowleri trophozoites under the non-contact condition for 30 min, 2 hr, and 4 hr, the levels of cytotox-icity of target cells were 32.3, 35.5, and 37.8%, respectively. Particularly, when the ratio of amoeba to target cells is 10 to 1, the level of cytotoxicity of target cells was 49.7% at 30 min. To show the proteins secreted from N. fowleri under the non-contact condition, we carried out 2D electrophoresis and observed 6 major proteins. Finally, these results suggest that the molecules released from N. fowleri un-der the non-contact condition induce the cell death and this process is an important step in pathogenesis of N. fowleri.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Anderson K / 1972 / Primary amoebic meningoencephalitis / Lancet 19:379
Apley J / 1970 / Primary amoebic meningoencephalitis in Britain / Br Med J 7:596~599
Barbour SE / 2001 / Naegleria fowleri amoebae express a membrane-associated calcium-independent phospholipase A / Biochim Biophys Acta 1530:123~133
Carter RF / 1968 / Primary amoebic meningoencephalitis : clinical, pathological and epidemiological features of six fatal cases / J Pathol Bacteriol 96:1~25
Carter RF / 1970 / Description of a Naegleria species isolated from two cases of primary amoebic meningoencephalitis and of the experimental pathological changes induced by it / J Pathol 100:217~244
Apley J / 1970 / Primary amoebic meningoencephalitis in Britain / Br Med J 7:596~599
Barbour SE / 2001 / Naegleria fowleri amoebae express a membrane-associated calcium-independent phospholipase A / Biochim Biophys Acta 1530:123~133
Carter RF / 1968 / Primary amoebic meningoencephalitis : clinical, pathological and epidemiological features of six fatal cases / J Pathol Bacteriol 96:1~25
Carter RF / 1970 / Description of a Naegleria species isolated from two cases of primary amoebic meningoencephalitis and of the experimental pathological changes induced by it / J Pathol 100:217~244
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