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MiR-1299 functions as a tumor suppressor to inhibit the proliferation and metastasis of gastric cancer by targeting ARF6
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논문 기본 정보

Type
Academic journal
Author
Qiu Yang (Jiangxi Cancer Hospital China) Yuan Yonggang (People’s Hospital of Lujiang County China) Luo Ping (Nanchang Third Hospital China)
Journal
한국유전학회 Genes & Genomics Genes & Genomics Vol.44 No.2 KCI Accredited Journals
Published
2022.2
Pages
237 - 245 (9page)
DOI
10.1007/s13258-021-01124-w

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MiR-1299 functions as a tumor suppressor to inhibit the proliferation and metastasis of gastric cancer by targeting ARF6
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Background MiRNAs belong to non-coding RNAs that are involved in cancer development. Acting as a mediator, they could regulate the expression level of numerous gens. However, the expression and function of miR-1299 in gastric cancer (GC) are not clear. Objective To explore the role of miR-1299 in the process of GC. Methods We detected the levels of miR-1299 in clinical samples of GC and investigated the role of miR-1299 in the regulation of the GC cells proliferation, apoptosis and metastasis. Luciferase reporter assay was employed to verify the target of miR-1299. Additionally, the proliferation, apoptosis and metastasis of AGS and SGC7901 cells were analyzed after the overexpression of miR-1299. Results Our study showed the expression of miR-1299 was decreased in GC tissues and cell lines. It indicated that the cell proliferation, migration and invasion was inhibited, while the cell apoptosis was promoted by the over-expressed miR-1299. Also, we found that miR-1299 could directly target the 3′-untranslated region (3′UTR) of ARF6 genes. In addition, rescue assay demonstrated that miR-1299 overexpression promoted the cell apoptosis and inhibited cell growth, which could be attenuated by the overexpression of ARF6. Conclusions These findings indicate that miR-1299 regulates cell progression in GC by targeting ARF6 genes, and suggest that miR-1299 may be a tumor suppressor in the GC progression.
#MiR-1299 · ARF6 · Gastric cancer · Proliferation · Apoptosis

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