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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제3호
- 발행연도
- 2016.1
- 수록면
- 572 - 578 (7page)
이용수
초록· 키워드
오류제보하기
Communication between endothelial cells (ECs) and smooth muscle cells (SMCs) via miR-143/145 clusters is vital to vascular stability. Previous research demonstrates that miR-143/145 released from ECs can regulate SMC proliferation and migration. In addition, a recent study has found that SMCs also have the capability of manipulating EC function via miR-143/145. In the present study, we artificially increased the expression of miR-143/145 in ECs, to mimic a similar change caused by miR-143/145 released by SMCs, and applied untargeted metabolomics analysis, aimed at investigating the consequential effect of miR-143/145 overexpression. Our results showed that miR-143/145 overexpression alters the levels of metabolites involved in energy production, DNA methylation, and oxidative stress. These changed metabolites indicate that metabolic pathways, such as the SAM cycle and TCA cycle, exhibit significant differences from the norm with miR-143/145 overexpression.
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참고문헌 (26)
참고문헌 신청
Abramsson A / 2003 / Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors / J. Clin. Invest 112:1142~1151
Akao Y / 2007 / Downregulation of microRNAs-143 and -145 in B-cell malignancies / Cancer Sci 98:1914~1920
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116:281~297
Benjamin LE / 1998 / A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF / Development 125:1591~1598
Benton HP / 2014 / Autonomous metabolomics for rapid metabolite identification in global profiling / Anal. Chem 87:884~891
Akao Y / 2007 / Downregulation of microRNAs-143 and -145 in B-cell malignancies / Cancer Sci 98:1914~1920
Bartel DP / 2004 / MicroRNAs: genomics, biogenesis, mechanism, and function / Cell 116:281~297
Benjamin LE / 1998 / A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF / Development 125:1591~1598
Benton HP / 2014 / Autonomous metabolomics for rapid metabolite identification in global profiling / Anal. Chem 87:884~891
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