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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제2호
- 발행연도
- 2021.1
- 수록면
- 197 - 206 (10page)
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초록· 키워드
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microRNA-361-3p (miR-361-3p) is involved in the carcinogenesis of oral cancer and pancreatic catheter adenocarcinoma, and has anti-carcinogenic effects on non-small cell lung cancer (NSCLC). However, its effect on multiple myeloma (MM) is less reported. Here, we found that upregulating the expression of miR-361-3p inhibited MM cell viability and promoted MM apoptosis. We measured expressions of tumor necrosis factor receptor-associated factor 6 (TRAF6) and miR-361-3p in MM cells and detected the viability, colony formation rate, and apoptosis of MM cells. In addition, we measured expressions of apoptosis-related genes Bcl-2, Bax, and Cleaved caspase-3 (C caspase-3). The binding site between miR-361-3p and TRAF6 was predicted by TargetScan. Our results showed that miR-361-3p was low expressed in the plasma of MM patients and cell lines, while its overexpression inhibited viability and colony formation of MM cells and increased the cell apoptosis. Furthermore, TRAF6, which was predicted to be a target gene of miR-361-3p, was highexpressed in the plasma of patients and cell lines with MM. Rescue experiments demonstrated that the effect of TRAF6 on MM cells was opposite to that of miR-361-3p. Upregulation of miR-361-3p induced apoptosis and inhibited the proliferation of MM cells through targeting TRAF6, suggesting that miR-361-3p might be a potential target for MM therapy.
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참고문헌 (34)
참고문헌 신청
Adams JM / 2018 / The BCL-2 arbiters of apoptosis and their growing role as cancer targets / Cell Death Differ 25:27~36
Amodio N / 2017 / Epigenetic modifications in multiple myeloma : recent advances on the role of DNA and histone methylation / Expert Opin. Ther. Targets 21:91~101
Amodio N / 2016 / Therapeutic targeting of miR-29b/HDAC4epigenetic loop in multiple myeloma / Mol. Cancer Ther 15:1364~1375
Ivyna Pau Ni Bong / 2017 / MicroRNA expression patterns and target prediction in multiple myeloma development and malignancy / Genes & Genomics 39(5):533~540
Botta C / 2018 / MiR-29b antagonizes the pro-inflammatory tumorpromoting activity of multiple myeloma-educated dendritic cells / Leukemia 32:1003~1015
Amodio N / 2017 / Epigenetic modifications in multiple myeloma : recent advances on the role of DNA and histone methylation / Expert Opin. Ther. Targets 21:91~101
Amodio N / 2016 / Therapeutic targeting of miR-29b/HDAC4epigenetic loop in multiple myeloma / Mol. Cancer Ther 15:1364~1375
Ivyna Pau Ni Bong / 2017 / MicroRNA expression patterns and target prediction in multiple myeloma development and malignancy / Genes & Genomics 39(5):533~540
Botta C / 2018 / MiR-29b antagonizes the pro-inflammatory tumorpromoting activity of multiple myeloma-educated dendritic cells / Leukemia 32:1003~1015
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