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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 70 - 75 (6page)
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초록· 키워드
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MicroRNAs (miRNAs) have been demonstrated to play an important role in carcinogenesis. Previous studies revealed that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity. In this study, we measured the plasma expression levels of three miRNAs (miR-21, miR-27a, and miR-155) to investigate the usefulness of miRNAs for gastric cancer detection. We initially examined plasma miRNA expression levels in a screening cohort consisting of 15 patients with gastric cancer and 15 healthy controls from Korean population, using TaqMan quantitative real-time polymerase chain reaction. We observed that the expression level of miR-27a was significantly higher in patients with gastric cancer than in healthy controls, whereas the miR-21 and miR-155a expression levels were not significantly higher in the patients with gastric cancer. Therefore, we further validated the miR-27a expression level in 73 paired gastric cancer tissues and in a validation plasma cohort from 35 patients with gastric cancer and 35 healthy controls. In both the gastric cancer tissues and the validation plasma cohort, the miR-27a expression levels were significantly higher in patients with gastric cancer. Receiver-operator characteristic (ROC) analysis of the validation cohort, revealed an area under the ROC curve value of 0.70 with 75% sensitivity and 56% specificity in discriminating gastric cancer. Thus, the miR-27a expression level in plasma could be a useful biomarker for the diagnosis and/or prognosis of gastric cancer.
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참고문헌 (38)
참고문헌 신청
Parkin DM. / 2005 / Global cancer statistics, 2002 / CA Cancer J Clin 55:74~108
Rifai N. / 2006 / Protein biomarker discovery and validation : the long and uncertain path to clinical utility / Nat Biotechnol 24:971~983
V. Narry Kim / 2005 / Small RNAs: Classification, Biogenesis, and Function / Molecules and Cells 19(1):1~15
Bartel DP / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Bushati N. / 2007 / MicroRNA functions / Annu Rev Cell Dev Biol 23:175~205
Rifai N. / 2006 / Protein biomarker discovery and validation : the long and uncertain path to clinical utility / Nat Biotechnol 24:971~983
V. Narry Kim / 2005 / Small RNAs: Classification, Biogenesis, and Function / Molecules and Cells 19(1):1~15
Bartel DP / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Bushati N. / 2007 / MicroRNA functions / Annu Rev Cell Dev Biol 23:175~205
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