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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 117 - 125 (9page)
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Microglia regulate the secretion of various immunomediators in central nervous system diseases. Microglial autophagy is the crucial process for cell’s survival and cytokine productions. Recent studies have reported that several microRNAs are involved in the autophagy system. miR-Let7A is such a microRNA that plays a role in various inflammation responses, and is magnified as a key modulator particularly in the autophagy system. In present study, we investigated whether miR-Let7A is involved in autophagy in activating microglia. Overexpression of miR-Let7A in LPS-stimulated BV2 microglial cells promoted the induction of the autophagy related factors such as LC3II, Beclin1, and ATG3. Our results suggest a potential role of miR-Let7A in the autophagy process of microglia during CNS inflammation.
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참고문헌 (72)
참고문헌 신청
Jiang T / 2014 / Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy / Br J Pharmacol 171:3146~3157
Nelson MP / 2013 / Autophagy modulation in disease therapy: where do we stand? / Curr Pathobiol Rep 1:239~245
Urbanek T / 2014 / Rapamycin induces of protective autophagy in vascular endothelial cells exposed to oxygen-glucose deprivation / Brain Res 1553:1~11
Oka T / 2012 / Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure / Nature 485:251~255
Green DR / 2011 / Mitochondria and the autophagy-inflammation-cell death axis in organismal aging / Science 333:1109~1112
Nelson MP / 2013 / Autophagy modulation in disease therapy: where do we stand? / Curr Pathobiol Rep 1:239~245
Urbanek T / 2014 / Rapamycin induces of protective autophagy in vascular endothelial cells exposed to oxygen-glucose deprivation / Brain Res 1553:1~11
Oka T / 2012 / Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure / Nature 485:251~255
Green DR / 2011 / Mitochondria and the autophagy-inflammation-cell death axis in organismal aging / Science 333:1109~1112
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