지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 14 - 23 (10page)
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초록· 키워드
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PTEN-induced putative kinase 1 (PINK1) is a Parkinson’s disease (PD) gene. We examined miRNAs regulated by PINK1 during brain development and neural stem cell (NSC) differentiation, and found that lvels of miRNAs related to tumors and inflammation were different between 1-day-old-wild type (WT) and PINK1-knockout (KO) mouse brains. Notably, levels of miR-326, miR- 330 and miR-3099, which are related to astroglioma, increased during brain development and NSC differentiation, and were significantly reduced in the absence of PINK1. Interestingly, in the presence of ciliary neurotrophic factor (CNTF), which pushes differentiation of NSCs into astrocytes, miR-326, miR-330, and miR-3099 levels in KO NSCs were also lower than those in WT NSCs. Furthermore, mimics of all three miRNAs increased expression of the astrocytic marker glial fibrillary acidic protein (GFAP) during differentiation of KO NSCs, but inhibitors of these miRNAs decreased GFAP expression in WT NSCs. Moreover, these miRNAs increased the translational efficacy of GFAP through the 3’-UTR of GFAP mRNA. Taken together, these results suggest that PINK1 deficiency reduce expression levels of miR-326, miR-330 and miR-3099, which may regulate GFAP expression during NSC differentiation and brain development.
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참고문헌 (50)
참고문헌 신청
Valente EM / 2001 / Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36 / Am J Hum Genet 68:895~900
Petit A / 2005 / Wildtype PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations / J Biol Chem 280:34025~34032
Beilina A / 2005 / Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability / Proc Natl Acad Sci U S A 102:5703~5708
Liu W / 2009 / PINK1defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease / PLoS One 4:e4597
Sim CH / 2006 / C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1 / Hum Mol Genet 15:3251~3262
Petit A / 2005 / Wildtype PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations / J Biol Chem 280:34025~34032
Beilina A / 2005 / Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability / Proc Natl Acad Sci U S A 102:5703~5708
Liu W / 2009 / PINK1defect causes mitochondrial dysfunction, proteasomal deficit and alpha-synuclein aggregation in cell culture models of Parkinson's disease / PLoS One 4:e4597
Sim CH / 2006 / C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1 / Hum Mol Genet 15:3251~3262
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