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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- J-INSTITUTE International Journal of Martial Arts International Journal of Martial Arts 제2권 제1호
- 발행연도
- 2017.6
- 수록면
- 34 - 38 (5page)
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초록· 키워드
오류제보하기
Lipopolysaccharide(LPS)-induced neuroinflammation is associated with the pathogenesis of Alzheimer’s disease(AD), which is a key factor underlying the generation of amyloid beta. Requirements for therapies of neurodegenerative diseases such as AD are not only consistent efficacy for long periods, but also the elimination of potential risks for hepatotoxicity. Thus, this study aimed to evaluate the effect of Frunus mume water extract (FME) on LPS-induced hippocampal damage associated with inflammatory signals. ICR male mice(n=30) were divided into three groups. The normal group remained untreated, LPS group (positive control) was stimulated to express LPS-induced hippocampus damage, and FME group(treatment) was stimulated to express LPS-induced hippocampal damage and administered FME at 40 mg/kg/day. Mouse brain tissues were tested by hematoxylin and eosin staining and immunohistochemistry following inflammation markers such as tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase(iNOS), and cyclooxygenase-2(COX-2). FME administered at 40 mg/kg/day for seven days in saline solution significantly reduced brain inflammation in the hippocampi of LPS-stimulated mice. Moreover, FME regulated the expression of inflammatory proteins such as TNF-α, iNOS and COX-2. Our data exhibits that FME attenuates neuroinflammation and damage in brains of LPS-stimulated mice. These findings suggest that FME is a potential therapeutic agent in treating neuroinflammation and recommend further testing on the matter.
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등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Choonara YE / 2009 / Trends in the Molecular Pathogenesis and Clinical Therapeutics of Common Neuro-degenerative Disorders / International Jour-nal of Molecular Sciences 10:2510~2057
Hardy JA / 1992 / Alzheimer's Disease: The Amyloid Cascade Hypothesis / Science 256:184~185
Pratico D / 2000 / Inflammatory Hypotheses: Novel Mechanisms of Alzhei-mer's Neurodegeneration and New Thera-peutic Targets? / Neurobiology Aging 21:441~445
Lee JW / 2008 / Neuro-Inflammation Induced by Lipopolysaccharide Causes Cog-nitive Impairment through Enhancement of Beta-Amyloid Generation / Journal of Neu-roinflammation 5(1):37
Liu B / 2003 / Role of Microglia in Inflam-mation-Mediated Neurodegenerative Dis-eases: Mechanisms and Strategies for Thera-peutic Intervention / Journal of Pharmacol-ogy Experimental Therapeutics 304:1~7
Hardy JA / 1992 / Alzheimer's Disease: The Amyloid Cascade Hypothesis / Science 256:184~185
Pratico D / 2000 / Inflammatory Hypotheses: Novel Mechanisms of Alzhei-mer's Neurodegeneration and New Thera-peutic Targets? / Neurobiology Aging 21:441~445
Lee JW / 2008 / Neuro-Inflammation Induced by Lipopolysaccharide Causes Cog-nitive Impairment through Enhancement of Beta-Amyloid Generation / Journal of Neu-roinflammation 5(1):37
Liu B / 2003 / Role of Microglia in Inflam-mation-Mediated Neurodegenerative Dis-eases: Mechanisms and Strategies for Thera-peutic Intervention / Journal of Pharmacol-ogy Experimental Therapeutics 304:1~7
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