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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 339 - 349 (11page)
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초록· 키워드
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Osteopontin (OPN) is a secreted glycoprotein that is expressed in various tissues, including brain, and mediates a wide range of cellular activities. In a previous study, the authors observed the robust neuroprotective effects of recombinant OPN and of RGD and SLAYGLR-containing OPN-peptide icosamer (OPNpt20) in an animal model of transient focal ischemia, and demonstrated antiinflammatory and pro-angiogenic effects of OPNpt20 in the postischemic brain. In the present study, we investigated the effects of OPNpt20 on the motility and phagocytic activity of BV2 cells (a microglia cell line). F-actin polymerization and cell motility were significantly enhanced in OPNpt20-treated BV2 cells, and numbers of filopodia-like processes increased and lamellipodia-like structures enlarged and thickened. In addition, treatment of cells with either of three mutant OPN icosamers containing mutation within RGD, SLAY, or RGDSLAY showed that the RGD and SLAY motifs of OPNpt20 play critical roles in the enhancement of cell motility, and the interaction between exogenous OPNpt20 and endogenous αv and α4 integrin and the activations of FAK, Erk, and Akt signaling pathways were found to be involved in the OPNpt20-mediated induction of cell motility. Furthermore, phagocytic activity of microglia was also significantly enhanced by OPNpt20 in a RGD and SLAY dependent manner. These results indicate OPNpt20 containing RGD and SLAY motifs triggers microglial motility and phagocytic activity and OPNpt20-integrin mediated signaling plays a critical role in these activities.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Rittling SR / 2011 / Osteopontin in macrophage function / Expert Rev Mol Med 13:e15
Yan YP / 2009 / Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia / Neurochem Int 55:826~832
Suzuki H / 2010 / Mechanisms of osteopontin-induced stabilization of blood-brain barrier disruption after subarachnoid hemorrhage in rats / Stroke 41:1783~1790
Ailane S / 2013 / Expression of integrin and CD44 receptors recognising osteopontin in the normal and LPS-lesioned rat substantia nigra / Eur J Neurosci 38:2468~2476
Schroeter M / 2006 / Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice / Brain 129:1426~1437
Yan YP / 2009 / Osteopontin is a mediator of the lateral migration of neuroblasts from the subventricular zone after focal cerebral ischemia / Neurochem Int 55:826~832
Suzuki H / 2010 / Mechanisms of osteopontin-induced stabilization of blood-brain barrier disruption after subarachnoid hemorrhage in rats / Stroke 41:1783~1790
Ailane S / 2013 / Expression of integrin and CD44 receptors recognising osteopontin in the normal and LPS-lesioned rat substantia nigra / Eur J Neurosci 38:2468~2476
Schroeter M / 2006 / Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice / Brain 129:1426~1437
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