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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 547 - 553 (7page)
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초록· 키워드
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Synucleinopathies are neurodegenerative disorders characterized by the progressive accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). In this review, we consolidate our key findings and recent studies concerning the role of Toll-like receptor 2 (TLR2), a pattern recognition innate immune receptor, in the pathogenesis of synucleinopathies. First, we address the pathological interaction of α-syn with microglial TLR2 and its neurotoxic inflammatory effects. Then, we show that neuronal TLR2 activation not only induces abnormal α-syn accumulation by impairing autophagy, but also modulates α-syn transmission. Finally, we demonstrate that administration of a TLR2 functional inhibitor improves the neuropathology and behavioral deficits of a synucleinopathy mouse model. Altogether, we present TLR2 modulation as a promising immunotherapy for synucleinopathies.
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참고문헌 (56)
참고문헌 신청
Spillantini MG / 1997 / Alpha-synuclein in Lewy bodies / Nature 388:839~840
McCann H / 2014 / α-Synucleinopathy phenotypes / Parkinsonism Relat Disord 20(Suppl 1):S62~S67
Masliah E / 2000 / Dopaminergic loss and inclusion body formation in alpha-synuclein mice : implications for neurodegenerative disorders / Science 287:1265~1269
Lashuel HA / 2013 / The many faces of α-synuclein : from structure and toxicity to therapeutic target / Nat Rev Neurosci 14:38~48
Lee HJ / 2005 / Intravesicular localization and exocytosis of alpha-synuclein and its aggregates / J Neurosci 25:6016~6024
McCann H / 2014 / α-Synucleinopathy phenotypes / Parkinsonism Relat Disord 20(Suppl 1):S62~S67
Masliah E / 2000 / Dopaminergic loss and inclusion body formation in alpha-synuclein mice : implications for neurodegenerative disorders / Science 287:1265~1269
Lashuel HA / 2013 / The many faces of α-synuclein : from structure and toxicity to therapeutic target / Nat Rev Neurosci 14:38~48
Lee HJ / 2005 / Intravesicular localization and exocytosis of alpha-synuclein and its aggregates / J Neurosci 25:6016~6024
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