지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 113 - 119 (7page)
이용수
초록· 키워드
오류제보하기
Synucleinopathies are a collection of neurological diseases that are characterized by deposition of α-synuclein aggregates in neurons and glia. These diseases include Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. Although it has been increasingly clear that α-synuclein is implicated in the pathogenesis of PD and other synucleinopathies, the precise mechanism underlying the disease process remains to be unraveled. The past studies on how α-synuclein exerts pathogenic actions have focused on its direct, cell-autonomous neurotoxic effects. However, recent findings suggested that there might be indirect, non-cell-autonomous pathways, perhaps through the changes in glial cells, for the pathogenic actions of this protein. Here, we present evidence that α-synuclein can cause neurodegeneration through a non-cell-autonomous manner. We show that α-synuclein can be secreted from neurons and induces inflammatory responses in microglia, which in turn secreted neurotoxic agents into the media causing neurodegeneration. The neurotoxic response of microglia was mediated by activation of toll-like receptor 2 (TLR2), a receptor for neuron-derived α-synuclein. This work suggests that TLR2 is the key molecule that mediates non-cell-autonomous neurotoxic effects of α-synuclein, hence a candidate for the therapeutic target.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
McCann H / 2014 / Alpha-synucleinopathy phenotypes / Parkinsonism Relat Disord 20(Suppl 1):S62~S67
Lashuel HA / 2013 / The many faces of alpha-synuclein: from structure and toxicity to therapeutic target / Nat Rev Neurosci 14:38~48
Cookson MR / 2009 / Alpha-synuclein and neuronal cell death / Mol Neurodegener 4:9
2003 / Abstracts of the 25th Annual Meeting of the American Society for Bone and Mineral Research. Minneapolis, Minnesota, USA. September 19-23, 2003 / J Bone Miner Res 18(Suppl 2):S2~S463
Mollenhauer B / 2010 / Quantification of alpha-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies / Biomarkers Med 4:683~699
Lashuel HA / 2013 / The many faces of alpha-synuclein: from structure and toxicity to therapeutic target / Nat Rev Neurosci 14:38~48
Cookson MR / 2009 / Alpha-synuclein and neuronal cell death / Mol Neurodegener 4:9
2003 / Abstracts of the 25th Annual Meeting of the American Society for Bone and Mineral Research. Minneapolis, Minnesota, USA. September 19-23, 2003 / J Bone Miner Res 18(Suppl 2):S2~S463
Mollenhauer B / 2010 / Quantification of alpha-synuclein in cerebrospinal fluid as a biomarker candidate: review of the literature and considerations for future studies / Biomarkers Med 4:683~699
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells
Experimental Neurobiology
2020 .01
-
Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies
Experimental Neurobiology
2019 .01
-
Monitoring α-synuclein Aggregation Induced by Preformed α-synuclein Fibrils in an In Vitro Model System
Experimental Neurobiology
2023 .06
-
Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson’s Disease
Experimental Neurobiology
2021 .01
-
Prothrombin Kringle-2: A Potential Inflammatory Pathogen in the Parkinsonian Dopaminergic System
Experimental Neurobiology
2016 .01
-
L-DOPA-Induced Dyskinesia in a Genetic Drosophila Model of Parkinson’s Disease
Experimental Neurobiology
2020 .01
-
〈The Cell〉
International Digital Design Invitation Exhibition
2016 .12
-
Cell.7
International Digital Design Invitation Exhibition
2018 .05
-
Optogenetic Glia Manipulation: Possibilities and Future Prospects
Experimental Neurobiology
2016 .01
-
Upregulation of Toll-like Receptor 2 in Dental Primary Afferents Following Pulp Injury
Experimental Neurobiology
2021 .10
-
Astrocytes, Microglia, and Parkinson’s Disease
Experimental Neurobiology
2018 .01
-
An Automated Cell Detection Method for TH-positive Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease Using Convolutional Neural Networks
Experimental Neurobiology
2023 .06
-
CELL-X(Cell Proliferation)
한국콘텐츠학회 ICCC 논문집
2022 .12
-
CELL-X(Cell Proliferation)
International Digital Design Invitation Exhibition
2022 .12
-
Mitochondrial Dysfunction in Parkinson's Disease
Experimental Neurobiology
2015 .01
-
World Cell
International Digital Design Invitation Exhibition
2021 .12
-
Cells in Space
International Digital Design Invitation Exhibition
2018 .07
-
Analgesic Effect of Toll-like Receptor 4 Antagonistic Peptide 2 on Mechanical Allodynia Induced with Spinal Nerve Ligation in Rats
Experimental Neurobiology
2019 .01
-
Information Necessity Analysis in the Autonomous Vehicle Environment
한국HCI학회 학술대회
2017 .02
-
Cell Type-specific Knockout with Gli1-mediated Cre Recombination in the Developing Cerebellum
Experimental Neurobiology
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0