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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 643 - 657 (15page)
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초록· 키워드
오류제보하기
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of aging have been reported to be associated with progressively compromised autophagy. Dysfunctional autophagy may contribute to age-related diseases, such as neurodegenerative disease, cancer, and metabolic syndrome, in the elderly. Therefore, restoration of impaired autophagy to normal may help to prevent age-related disease and extend lifespan and longevity. Therefore, this review aims to provide an overview of the mechanisms of autophagy underlying cellular aging and the consequent disease. Understanding the mechanisms of autophagy may provide potential information to aid therapeutic interventions in age-related diseases.
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등록된 정보가 없습니다.
참고문헌 (167)
참고문헌 신청
Rubinsztein DC / 2011 / Autophagy and aging / Cell 146:682~695
Hansen M / 2018 / Autophagy as a promoter of longevity : insights from model organisms / Nat Rev Mol Cell Biol 19:579~593
López-Otín C / 2013 / The hallmarks of aging / Cell 153:1194~1217
Balaban RS / 2005 / Mitochondria, oxidants, and aging / Cell 120:483~495
Seluanov A / 2004 / DNA end joining becomes less efficient and more error-prone during cellular senescence / Proc Natl Acad Sci U S A 101:7624~7629
Hansen M / 2018 / Autophagy as a promoter of longevity : insights from model organisms / Nat Rev Mol Cell Biol 19:579~593
López-Otín C / 2013 / The hallmarks of aging / Cell 153:1194~1217
Balaban RS / 2005 / Mitochondria, oxidants, and aging / Cell 120:483~495
Seluanov A / 2004 / DNA end joining becomes less efficient and more error-prone during cellular senescence / Proc Natl Acad Sci U S A 101:7624~7629
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