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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Alcoholic steatosis is a fundamental metabolic disorder and may precede the onset of more severe forms of alcoholic liver disease. In this study, we isolated enzymatichydrolysate from Semisulcospira libertine by alcalase hydrolysis and investigated the protective effect of Semisulcospira libertine hydrolysate on liver injury induced by alcohol in the mouse model of chronic and binge ethanol feeding (NIAAA). In an in vitro study, the hydrolysate protects HepG2 cells from ethanol toxicity. Liver damage was assessed by histopathological examination, as well as by quantitating activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). After the administration of S. libertina hydrolysate, fat accumulation and infiltration of inflammatory cells in liver tissues were significantly decreased in the NIAAA mouse model. The elevated levels of serum AST, ALT, and ALP activities, along with the lipid contents of a damaged liver, were recovered in experimental mice administrated with S. libertina hydrolysate, suggesting its role in blood enzyme activation and lipid content restoration within damaged liver tissues. Moreover, treatment with S. libertine hydrolysate reduced the expression rate of cyclooxygenase (COX-2), interleukin (IL)-1β, and IL-6, which accelerate inflammation and induces tissue damage. All data showed that S. libertine hydrolysate has a preventive role against alcohol-induced liver damages by improving the activities of blood enzymes and modulating the expression of inflammation factor, suggesting S. libertine hydrolysate could be a commercially potential material for the restoration of hepatotoxicity.
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참고문헌 (6)
참고문헌 신청
조재민 / 2016 / Protective Effect of Silkworm (Bombyx mori) Powder against Diethylnitrosamine-induced Hepatotoxicity in Mice / 산업식품공학 20(4):342~348
조경환 / 2017 / 간세포 독성과 에탄올 대사에서 추출 조건에 따른 다슬기 추출물의 효과 / 산업식품공학 20(2):158~166
최지휘 / 2014 / 알코올성 지방간을 유발시킨 마우스에서 유산균 발효 마늘추출물의 간 보호 효과 / 한국식품영양과학회지 43(11):1642~1647
김연계 / 2009 / 국내산 7종 다슬기 추출물의 생리활성 특성 비교 / 한국수산과학회지 42(5):434~441
임치원 / 2009 / 한국산 다슬기의 식품학적 성분 및 품질특성 / 한국수산과학회지 42(6):555~560
조경환 / 2017 / 간세포 독성과 에탄올 대사에서 추출 조건에 따른 다슬기 추출물의 효과 / 산업식품공학 20(2):158~166
최지휘 / 2014 / 알코올성 지방간을 유발시킨 마우스에서 유산균 발효 마늘추출물의 간 보호 효과 / 한국식품영양과학회지 43(11):1642~1647
김연계 / 2009 / 국내산 7종 다슬기 추출물의 생리활성 특성 비교 / 한국수산과학회지 42(5):434~441
임치원 / 2009 / 한국산 다슬기의 식품학적 성분 및 품질특성 / 한국수산과학회지 42(6):555~560
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