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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 65 - 71 (7page)
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초록· 키워드
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Purpose: We investigated whether consecutive levels of new emerging renal biomarkers, including serum cystatin C (CysC) and urinary neutrophil gelatinase-associated lipocalin (NGAL)/creatinine (Cr) ratio, were affected by postconceptional age in very-low-birth-weight (VLBW) infants. Methods: Repeatedly measured samples for each infant were divided into four groups according to postnatal age: at birth (stage I), 3 to 7 days postnatally (stage II), 8 to 28 days postnatally (stage III), and >28 days postnatally (stage IV). The association between renal biomarkers and postconceptional age was assessed using Pearson’s correlation coefficient, and the mean values of renal biomarkers in the four stages were compared using repeated-measures analysis of variance. Results: For samples measured at birth, serum CysC (r=?0.358, P=0.032) and urinary NGAL/Cr ratio (r=?0.522, P=0.001) were negatively correlated with gestational age, whereas serum Cr (r=0.148, P=0.390) was not. In addition, for all samples measured, serum CysC (r=?0.209, P=0.012), urinary NGAL/Cr ratio (r=?0.536, P<0.001), and serum Cr (r=?0.311, P<0.001) were negatively correlated with postconceptional age. Compared with the mean values of the postnatal age-specific stages, serum CysC showed no significant differences in any of the four stages. However, the urinary NGAL/Cr ratio in stage IV was significantly different from those in stages I to III. Conclusion: Although urinary NGAL/Cr ratio and serum CysC were negatively correlated with postconceptional age considering renal development, serum CysC showed no significant differences in any of the four postnatal age-specific stages. Urinary NGAL/Cr ratio at >28 days postnatally seems to be more affected by postconceptional age than serum CysC in VLBW infants.
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참고문헌 (39)
참고문헌 신청
Askenazi DJ / 2009 / Acute kidney injury is independently associated with mortality in very low birthweight infants : a matched case-control analysis / Pediatr Nephrol 24:991~997
Koralkar R / 2011 / Acute kidney injury reduces survival in very low birth weight infants / Pediatr Res 69:354~358
Hinchliffe SA / 1991 / Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle / Lab Invest 64:777~784
Stelloh C / 2012 / Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria / Transl Res 159:80~89
Veille JC / 1998 / Renal hemodynamics : longitudinal study from the late fetal life to one year of age / J Matern Fetal Investig 8:6~10
Koralkar R / 2011 / Acute kidney injury reduces survival in very low birth weight infants / Pediatr Res 69:354~358
Hinchliffe SA / 1991 / Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and Cavalieri principle / Lab Invest 64:777~784
Stelloh C / 2012 / Prematurity in mice leads to reduction in nephron number, hypertension, and proteinuria / Transl Res 159:80~89
Veille JC / 1998 / Renal hemodynamics : longitudinal study from the late fetal life to one year of age / J Matern Fetal Investig 8:6~10
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