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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Purpose: Acute kidney injury (AKI) is a common, serious complication in rhabdomyolysis patients. Early recognition and adequate therapy in rhabdomyolysis-related AKI are essential to reducing mortality. However, existing biomarkers, such as plasma creatinine, have several limitations for early detection of AKI. Novel parameters have recently been studied for greater reliability in prediction and staging of AKI in critically ill patients in the emergency department. The aim of this study is to evaluate the role of certain parameters for early prediction and staging of AKI in adults with acute non-traumatic rhabdomyolysis. Methods: Eighty eight patients with adult non-traumatic rhabdomyolysis, who were admitted to the emergency intensive care unit (ICU) from Dec 2013 to Nov 2014, were enrolled in this observational cohort study. AKI was defined according to the Acute Kidney Injury Network (AKIN) criteria. Diagnostic characteristics of initial laboratory parameters were analyzed using the area under the receiver operating characteristic (ROC) curve. Results: Of the 88 patients, 60 patients (68.2%) developed AKI during the ICU stay. The ROC curve for plasma neutrophil gelatinase-associated lipocalin (NGAL) showed the highest sensitivity (81.7%) and specificity (78.6%) among initial parameters. In pairwise comparison, the areas under the curve (AUCs) for plasma NGAL and serum creatinine were 0.868 (95% confidence interval [CI]: 0.779-0.931) and 0.765 (95% CI: 0.662-0.849), respectively. A statistically significant difference was observed in both (p=0.047). Plasma NGAL levels increased significantly as the stage of AKI progressed, using AKIN criteria (p<0.001). Conclusion: Plasma NGAL can be a reliable parameter for early prediction and approximate staging of AKI in adult nontraumatic rhabdomyolysis in the emergency department.
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참고문헌 (27)
참고문헌 신청
Bosch X / 2009 / Rhabdomyolysis and acute kidney injury / N Engl J Med 361:62~72
Petejova N / 2014 / Acute kidney injury due to rhabdomyolysis and renal replacement therapy : A critical review / Crit Care 18:224
Clerico A / 2012 / Neutrophil gelatinase-associated lipocalin(NGAL)as biomarker of acute kidney injury : A review of the laboratory characteristics and clinical evidences / Clin Chem Lab Med 50:1505~1517
Haase M / 2011 / The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury : A multicenter pooled analysis of prospective studies / J Am Coll Cardiol 57:1752~1761
Sharp LS / 2004 / Rhabdomyolysis and secondary renal failure in critically ill surgical patients / Am J Surg 188:801~806
Petejova N / 2014 / Acute kidney injury due to rhabdomyolysis and renal replacement therapy : A critical review / Crit Care 18:224
Clerico A / 2012 / Neutrophil gelatinase-associated lipocalin(NGAL)as biomarker of acute kidney injury : A review of the laboratory characteristics and clinical evidences / Clin Chem Lab Med 50:1505~1517
Haase M / 2011 / The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury : A multicenter pooled analysis of prospective studies / J Am Coll Cardiol 57:1752~1761
Sharp LS / 2004 / Rhabdomyolysis and secondary renal failure in critically ill surgical patients / Am J Surg 188:801~806
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