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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 79 - 88 (10page)
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초록· 키워드
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Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as one of the most promising biomarkers of renal epithelial injury. Numerous studies have presented the diagnostic and prognostic utility of urinary and plasma NGAL in patients with acute kidney injury, chronic kidney disease, renal injury after kidney transplantation, and other renal diseases. NGAL is a member of the lipocalin family that is abundantly expressed in neutrophils and monocytes/macrophages and is a mediator of the innate immune response. The biological significance of NGAL to hamper bacterial growth by sequestering iron-binding siderophores has been studied in a knock-out mouse model. Besides neutrophils, NGAL is detectable in most tissues normally encountered by microorganisms, and its expression is upregulated in epithelial cells during inflammation. A growing number of studies have supported the clinical utility of NAGL for detecting invasive bacterial infections. Several investigators including our group have reported that measuring NGAL can be used to help predict and manage urinary tract infections and acute pyelonephritis. This article summarizes the biology and pathophysiology of NGAL and reviews studies on the implications of NGAL in various renal diseases from acute kidney injury to acute pyelonephritis.
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참고문헌 (22)
참고문헌 신청
Berger
Bolignano D / 2008 / Pathological and prognostic value of urinary neutrophil gelatinaseassociated lipocalin (NGAL) in macroproteinuric patients with worsening renal function
Bolignano D / 2009 / Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease / Clin J Am Soc Nephrol 4 : 337 ~ 344
Borregaard N / 2006 / Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein / Biometals 19 : 211 ~ 215
Devireddy LR / 2005 / A cell surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake / Cell 123 : 1293 ~ 1305
Bolignano D / 2008 / Pathological and prognostic value of urinary neutrophil gelatinaseassociated lipocalin (NGAL) in macroproteinuric patients with worsening renal function
Bolignano D / 2009 / Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease / Clin J Am Soc Nephrol 4 : 337 ~ 344
Borregaard N / 2006 / Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein / Biometals 19 : 211 ~ 215
Devireddy LR / 2005 / A cell surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake / Cell 123 : 1293 ~ 1305
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Prediction of Renal Function Recovery Using Urine Output, Ngal and Creatinine in Surgical Critical Patients After Continuous Renal Replacement Therapy
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Clostridioides (Clostridium) difficile 감염에서 대변 Neutrophil Gelatinase-Associated Lipocalin과 Calprotectin의 생물학적 표지자로서의 임상적 유용성
Laboratory Medicine Online
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Hepatotoxicity aggravates cisplatin-induced acute kidney injury in Sprague-Dawley rats
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The associations of Urinary Neutrophil Gelatinaseassociated Lipocalin (NGAL) and Liver-type Fatty Acid Binding Protein (L-FABP) Levels with Hematuria in Children and Adolescents
Childhood Kidney Diseases
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Proenkephalin, Neutrophil Gelatinase-Associated Lipocalin, and Estimated Glomerular Filtration Rates in Patients With Sepsis
Annals of Laboratory Medicine
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Acute Kidney Injury
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The association between acute kidney injury in renal infarction and progression to chronic kidney disease
Kidney Research and Clinical Practice
2016 .01
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Intra-abdominal hypertension does not predict renal recovery or in-hospital mortality in critically ill patients with acute kidney injury
Kidney Research and Clinical Practice
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T helper 17 cells in the pathophysiology of acute and chronic kidney disease
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