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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 338 - 346 (9page)
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초록· 키워드
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Background: The most common cause of acute kidney injury (AKI) in pregnancy is preeclampsia. Serum cystatin C (CysC) is a potential biomarker of early kidney damage as its levels are not disturbed by volume status changes in pregnancy, and serum CysC levels could serve as a replacement for conventionally used creatinine. In this study, we investigated the serum levels of CysC in severe preeclampsia cases and the associations between CysC levels and poor obstetric outcomes. Methods: Our cohort included severe preeclampsia patients with a normal serum creatinine level. Creatinine was measured to calculate estimated glomerular filtration rate (eGFR) based on the Cockcroft and Gault, Modification of Diet in Renal Disease Study (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, while CysC was measured to calculated eGFR based on a CysC-based equation. We then evaluated the correlations between serum CysC level, eGFR, and obstetric outcomes. Results: Twenty-six patients were evaluated of which 38.5% delivered preterm and 30.8% had low-birth weight babies. Unlike creatinine-based eGFR and CysC-based eGFR, serum CysC demonstrate significant negative correlation with gestational age. Receiver operating characteristic curve analysis indicated that serum CysC is a potential biomarker of preterm delivery with a cut-off serum level of 1.48 mg/L with 80% sensitivity and 75% specificity. Conclusion: GFR estimation using CysC is likely to be inaccurate in pregnancy. However, we found a significant correlation between preterm delivery and serum CysC level. Our results suggest that serum CysC level has the potential to predict preterm delivery in severe preeclampsia patients.
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참고문헌 (59)
참고문헌 신청
Ananth CV / 2013 / Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis / BMJ 347:f6564
Saleem S / 2014 / A prospective study of maternal, fetal and neonatal deaths in low- and middle-income countries / Bull World Health Organ 1:605~612
Souza JP / 2013 / Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health): a cross-sectional study / Lancet 381:1747~1755
Hansen AR / 2010 / Maternal preeclampsia predicts the development of bronchopulmonary dysplasia / J Pediatr 156:532~536
Strand KM / 2013 / Mediators of the association between pre-eclampsia and cerebral palsy:population based cohort study / BMJ 347:f4089
Saleem S / 2014 / A prospective study of maternal, fetal and neonatal deaths in low- and middle-income countries / Bull World Health Organ 1:605~612
Souza JP / 2013 / Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health): a cross-sectional study / Lancet 381:1747~1755
Hansen AR / 2010 / Maternal preeclampsia predicts the development of bronchopulmonary dysplasia / J Pediatr 156:532~536
Strand KM / 2013 / Mediators of the association between pre-eclampsia and cerebral palsy:population based cohort study / BMJ 347:f4089
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