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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 151 - 162 (12page)
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Background/Aims: Correct renal function evaluation is based on estimated glomerular filtration rates (eGFR) and complementary renal damage biomarkers, such as neutrophil gelatinase associated lipocalin (NGAL). The aim of this study was to evaluate eGFR and NGAL modifications and renal impairment during treatment with a direct acting antiviral (DAA) for chronic hepatitis C virus (HCV) infection. Methods: A retrospective cohort study evaluated eGFR modification during treatment with DAA. Subgroup analysis on serum NGAL was conducted in those receiving sofosbuvir/ledipasvir, with complete follow-up until week 12 after the end of treatment (FU-12). Results: In the 102 enrolled patients, eGFR reduction was observed (from 86.22 mL/min at baseline to 84.43 mL/min at FU-12, P=0.049). Mean NGAL increased in 18 patients (from 121.89 ng/mL at baseline to 204.13 ng/mL at FU-12, P=0.014). At FU-12, 38.8% (7/18) of patients had a plasmatic NGAL value higher than the normal range (36-203 ng/mL) compared with 11.1% (2/18) at baseline (χ2=3,704; P=0.054). In contrast, eGFR did not change significantly over the follow-up in this subgroup. Conclusions: In conclusion, compared to a negligible eGFR decline observed in the entire cohort analyzed, a significant NGAL increase was observed after HCV treatment with DAA in a small subgroup. This could reflect tubular damage during DAA treatment rather than glomerular injury.
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참고문헌 (32)
참고문헌 신청
Mendizabal M / 2017 / Chronic hepatitis C and chronic kidney disease: advances, limitations and unchartered territories / J Viral Hepat 24:442~453
American Association for the Study of the Liver Diseases / 0000 / Recommendations for testing, managing, and treating hepatitis C
European Association for the Study of the Liver / 2017 / EASL Recommendations on Treatment of Hepatitis C 2016 / J Hepatol 66:153~194
Mucke MM / 2017 / Special populations: treating hepatitis C in patients with decompensated cirrhosis and/or advanced renal impairment / Liver Int 37(Suppl 1):19~25
Nazario HE / 2016 / Sofosbuvir and simeprevir in hepatitis C genotype 1-patients with end-stage renal disease on haemodialysis or GFR <30 ml/min / Liver Int 36:798~801
American Association for the Study of the Liver Diseases / 0000 / Recommendations for testing, managing, and treating hepatitis C
European Association for the Study of the Liver / 2017 / EASL Recommendations on Treatment of Hepatitis C 2016 / J Hepatol 66:153~194
Mucke MM / 2017 / Special populations: treating hepatitis C in patients with decompensated cirrhosis and/or advanced renal impairment / Liver Int 37(Suppl 1):19~25
Nazario HE / 2016 / Sofosbuvir and simeprevir in hepatitis C genotype 1-patients with end-stage renal disease on haemodialysis or GFR <30 ml/min / Liver Int 36:798~801
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