지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 164 - 170 (7page)
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초록· 키워드
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Purpose: Neutrophil gelatinase-associated lipocalin (NGAL) has been identified as an early marker of acute kidney injury (AKI). This study was designed to evaluate the clinical utility of the rapid plasma NGAL assay for diagnosing AKI in critically ill newborn infants in the neonatal intensive care unit (NICU).
Methods: The medical records of 178 critically ill newborn infants >34 weeks of gestational age who underwent plasma NGAL measurement during the first week of life in the Korea University Ansan Hospital NICU from February 2011 to August 2015 were retrospectively reviewed. Plasma NGAL levels were measured at bedside by using a commercial competitive immunoassay kit simultaneously with serum creatinine (Cr) level determination.
Results: Of 178 newborn infants enrolled in this study (study group), 25 infants had AKI (AKI group) while 153 infants had no AKI (control group). The plasma NGAL level in the AKI group (114.0 [76.5–281.5] ng/mL) was significantly higher than that in the control group (74.0 [52.5–122.5] ng/mL, P=0.001). Moreover, plasma NGAL levels were found to be correlated with serum Cr levels in the study group (r=0.208, P= 0.005). Plasma NGAL achieved an area under the receiver operating characteristic curve of 0.705 for detecting AKI (95% confidence interval: 0.593–0.817). The best cutoff plasma NGAL level for AKI diagnosis was 100 ng/mL.
Conclusion: The rapid plasma NGAL assay has diagnostic value for AKI in critically ill newborn infants >34 weeks of gestational age. Further investigations with a larger population are needed to confirm the potential use of plasma NGAL levels for diagnosing AKI in newborn infants.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Abitbol CL / 2003 / Long-term follow-up of extremely low birth weight infants with neonatal renal failure / Pediatr Nephrol 18 : 887 ~ 893
Abrahamson DR / 1994 / Glomerulogenesis in the developing kidney / Semin Nephrol 11 : 375 ~ 389
Askenazi DJ / 2009 / Acute kidney injury in critically ill newborns: what do we know? What do we need to learn? / Pediatr Nephrol 24 : 265 ~ 274
Askenazi DJ / 2011 / Urine biomarkers predict acute kidney injury and mortality in very low birth weight infants / J Pediatr 159 : 907 ~ 912
Atiyeh BA / 1996 / Evaluation of renal function during childhood / Pediatr Rev 17 : 175 ~ 180
Abrahamson DR / 1994 / Glomerulogenesis in the developing kidney / Semin Nephrol 11 : 375 ~ 389
Askenazi DJ / 2009 / Acute kidney injury in critically ill newborns: what do we know? What do we need to learn? / Pediatr Nephrol 24 : 265 ~ 274
Askenazi DJ / 2011 / Urine biomarkers predict acute kidney injury and mortality in very low birth weight infants / J Pediatr 159 : 907 ~ 912
Atiyeh BA / 1996 / Evaluation of renal function during childhood / Pediatr Rev 17 : 175 ~ 180
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