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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 182 - 187 (6page)
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When cells are stimulated by growth factors, they make a critical choice in early G1 phase: proceed forward to S phase, remain in G1, or revert to G0 phase. Once the critical decision is made, cells execute a fixed program independently of extracellular signals. The specific stage at which the critical decision is made is called the restriction point or R-point. The existence of the R-point raises a major question: what is the nature of the molecular machinery that decides whether or not a cell in G1 will continue to advance through the cell cycle or exit from the cell cycle? The R-point program is perturbed in nearly all cancer cells. Therefore, exploring the nature of the R-point decision-making machinery will provide insight into how cells consult extracellular signals and intracellular status to make an appropriate R-point decision, as well into the development of cancers. Recent studies have shown that expression of a number of immediate early genes is associated with the R-point decision, and that the decision-making program constitutes an oncogene surveillance mechanism. In this review, we briefly summarize recent findings regarding the mechanisms underlying the context-dependent R-point decision.
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참고문헌 (31)
참고문헌 신청
Belkina, A. C. / 2012 / BET domain co-regulators in obesity, inflammation and cancer / Nat. Rev. Cancer 12:465~477
Blagosklonny, M. V / 2006 / Cell senescence : hypertrophic arrest beyond the restriction point / J. Cell. Physiol 209:592~597
Cao, R. / 2002 / Role of histone H3 lysine 27 methylation in Polycomb-group silencing / Science 298:1039~1043
Cheng, M. / 1999 / The p21(Cip1)and p27(Kip1)CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts / EMBO J 18:1571~1583
Chi, X. Z. / 2017 / Runx3plays a critical role in restriction-point and defense against cellular transformation / Oncogene 36:6884~6894
Blagosklonny, M. V / 2006 / Cell senescence : hypertrophic arrest beyond the restriction point / J. Cell. Physiol 209:592~597
Cao, R. / 2002 / Role of histone H3 lysine 27 methylation in Polycomb-group silencing / Science 298:1039~1043
Cheng, M. / 1999 / The p21(Cip1)and p27(Kip1)CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts / EMBO J 18:1571~1583
Chi, X. Z. / 2017 / Runx3plays a critical role in restriction-point and defense against cellular transformation / Oncogene 36:6884~6894
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