지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 412 - 417 (6page)
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초록· 키워드
오류제보하기
Background: Chemokines and their receptors are important players in tumorigenesis by facilitating tumor proliferation and metastasis. Little is known about the possible function of chemokine receptors in relation to the development and progression of malignant cutaneous tumors. Objective: The aim of this study was to determine the chemokine receptor CCR3 expression pattern and the protein expression level in selected malignant cutaneous tumors. Methods: Four types of cell lines (G361, A431, SK-MEL-2, SK-MEL-24) were analyzed, using Western blotting, for the expression of CCR3protein. Immunohistochemical staining for CCR3 was done on 36 skin cancer tissue samples that included 16 squamous cell carcinomas (SCCs), 16 basal cell carcinomas (BCCs), 16malignant melanomas (MMs) and 6 normal tissue samples.
Results: Western blot analysis showed that CCR3 protein was more expressed in the MM cell lines (G361, SK-MEL-2,SK-MEL-24) than that in the SCC cell line (A431), and the immunohistochemical analysis showed that CCR3 protein was overexpressed in MM and SCC, it was mildly expressed in BCC and it was hardly expressed in normal tissue.
Conclusion: This study demonstrated via immunochemistry that CCR3 was more expressed in MM, followed by SCC and BCC. The existence of CCR3 protein may enhance the tumorigenic potential of malignant cutaneous tumors. (Ann Dermatol 22(4) 412∼417, 2010)
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Balkwill F / 2004 / Cancer and the chemokine network / Nat Rev Cancer 4 : 540 ~ 550
Coussens LM / 2002 / Inflammation and cancer / Nature 420 : 860 ~ 867
Dieu MC / 1998 / Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites / J Exp Med 188 : 373 ~ 386
Johrer K / 2005 / Up-regulation of functional chemokine receptor CCR3 in human renal cell carcinoma / Clin Cancer Res 11 : 2459 ~ 2465
Kleinhans M / 2003 / Functional expression of the eotaxin receptor CCR3 in CD30＋ cutaneous T-cell lymphoma / Blood 101 : 1487 ~ 1493
Coussens LM / 2002 / Inflammation and cancer / Nature 420 : 860 ~ 867
Dieu MC / 1998 / Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites / J Exp Med 188 : 373 ~ 386
Johrer K / 2005 / Up-regulation of functional chemokine receptor CCR3 in human renal cell carcinoma / Clin Cancer Res 11 : 2459 ~ 2465
Kleinhans M / 2003 / Functional expression of the eotaxin receptor CCR3 in CD30＋ cutaneous T-cell lymphoma / Blood 101 : 1487 ~ 1493
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