지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 173 - 181 (9page)
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초록· 키워드
오류제보하기
The CC chemokine receptor 5 (CCR5) is a G protein-coupled receptor that regulates chemotaxis and effector functions of immune cells. It also serves as the major co-receptor for the entry of human immunodeficiency virus (HIV). Recently, CCR5 inhibitors have been developed and used for the treatment or prevention of HIV infections. Additionally, it has been identified that CCR5 controls bone homeostasis by regulating osteoclastogenesis and the communication between osteoblasts and osteoclasts. However, the effects of CCR5 inhibition on bone tissue in elderly patients are unknown. This study aimed to examine the bone phenotype of aged CCR5 knockout (KO) mice. Femoral and tibial bones were isolated from 12-month and 18-month old wild-type (WT) and CCR5 KO mice, and microcomputed tomography and histology analyses were performed. Twelve-month-old CCR5 KO mice exhibited a decreased trabecular bone mass and cortical bone thickness in both femoral and tibial bones compared with age- matched WT mice. Eighteen-month-old mice also showed a decreased trabecular bone mass in femurs compared with control WT mice, but not in tibial bones. Unlike in 12-month-old mice, the cortical margin of femurs and tibias in 18-month-old mice were rough, likely because they were aggravated by the deficiency of CCR5. Overall, our data suggest that the deficiency of CCR5 with aging can cause severe bone loss. When CCR5 inhibitors or CCR5 inactivating technologies are used in elderly patients, a preventive strategy for bone loss should be considered.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Feng X / 2011 / Disorders of bone remodeling / Annu Rev Pathol 6:121~145
G. A. Rodan / 1998 / Bone homeostasis / Proceedings of the National Academy of Sciences 95(23):13361~13362
Nakashima T / 2012 / New insights into osteoclastogenic signaling mechanisms / Trends Endocrinol Metab 23:582~590
Samantha J. Allen / 2007 / Chemokine:Receptor Structure, Interactions, and Antagonism / Annual Review of Immunology 25(1):787~820
P. M. Murphy / 2002 / International Union of Pharmacology. XXX. Update on Chemokine Receptor Nomenclature / Pharmacological Reviews 54(2):227~229
G. A. Rodan / 1998 / Bone homeostasis / Proceedings of the National Academy of Sciences 95(23):13361~13362
Nakashima T / 2012 / New insights into osteoclastogenic signaling mechanisms / Trends Endocrinol Metab 23:582~590
Samantha J. Allen / 2007 / Chemokine:Receptor Structure, Interactions, and Antagonism / Annual Review of Immunology 25(1):787~820
P. M. Murphy / 2002 / International Union of Pharmacology. XXX. Update on Chemokine Receptor Nomenclature / Pharmacological Reviews 54(2):227~229
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