지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 65 - 74 (10page)
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초록· 키워드
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Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells that show increased expression in cancer patients; however, the molecular mechanisms underlying their generation and function are unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer (BC), the presence and relevance of monocytic (Mo)-MDSCs are unknown. Here, we report for the first time increased chemokine and chemokine receptor production by Mo-MDSCs in BC patients. A clear population of Mo-MDSCs with the typical cell surface phenotype (human leukocyte antigen-antigen D related [HLA-DR]<SUP>low/−</SUP> CD11b<SUP>+</SUP> CD33<SUP>+</SUP> CD14<SUP>+</SUP>) increased significantly during disease progression. In addition, the chemokine receptor expression level on Mo-MDSCs in patients with invasive BC was the highest. Furthermore, different chemokine receptor expression patterns were noted in Mo-MDSCs between healthy controls (HC) and BC patients. Additionally, CD4 T cells proliferations were significantly decreased in the invasive BC groups compared with the HC group. However, the ductal carcinoma in situ (DCIS) group had no significantly compared with the HC group. Our data suggest that monitoring chemokine and chemokine receptor production by Mo-MDSCs may represent a novel and simple biomarker for assessing disease progression in BC patients.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
Kusmartsev S / 2006 / Role of immature myeloid cells in mechanisms of immune evasion in cancer / Cancer Immunol Immunother 55:237~245
Gabrilovich DI / 2009 / Myeloid-derived suppressor cells as regulators of the immune system / Nat Rev Immunol 9:162~174
Vinay DS / 2015 / Immune evasion in cancer: mechanistic basis and therapeutic strategies / Semin Cancer Biol 35(Suppl):S185~S198
Marcus A / 2014 / Recognition of tumors by the innate immune system and natural killer cells / Adv Immunol 122:91~128
Sato Y / 2015 / Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma / OncoImmunology 4:e995541
Gabrilovich DI / 2009 / Myeloid-derived suppressor cells as regulators of the immune system / Nat Rev Immunol 9:162~174
Vinay DS / 2015 / Immune evasion in cancer: mechanistic basis and therapeutic strategies / Semin Cancer Biol 35(Suppl):S185~S198
Marcus A / 2014 / Recognition of tumors by the innate immune system and natural killer cells / Adv Immunol 122:91~128
Sato Y / 2015 / Characterization of the myeloid-derived suppressor cell subset regulated by NK cells in malignant lymphoma / OncoImmunology 4:e995541
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UCI(KEPA) : I410-ECN-0101-2018-517-003105525