지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 176 - 182 (7page)
이용수
초록· 키워드
오류제보하기
CCR3 is a chemokine receptor that mediates the accumulation of allergic inflammatory cells, including eosinophils and Th2 cells, at inflamed sites. The regulatory sequence of the CCR3 gene, contains two Runt-related transcription factor (RUNX) 1 sites and two PU.1 sites, in addition to a functional GATA site for transactivation of the CCR3 gene. In the present study, we examined the effects of the cis-acting elements of RUNX1 and PU.1 on transcription of the gene in EoL-1 eosinophilic cells and Jurkat T cells, both of which expressed functional surface CCR3 and these two transcription factors. Introduction of RUNX1 siRNA or PU.1 siRNA resulted in a modest decrease in CCR3 reporter activity in both cell types, compared with transfection of GATA-1 siRNA. Cotransfection of the two siRNAs led to inhibition in an additive manner. EMSA analysis showed that RUNX1, in particular, bound to its binding motifs. Mutagenesis analysis revealed that all point mutants lacking RUNX1- and PU.1-binding sites exhibited reduced reporter activities. These results suggest that RUNX1 and PU.1 participate in transcriptional regulation of the CCR3 gene.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] - Pease, J. E / 2006 / Chemokines and their receptors in allergic disease / J. Allergy Clin. Immunol 118 : 305 ~ 318
[학술지(정기간행물)] - Rothenberg, M. E / 2006 / The eosinophil / Annu. Rev. Immunol 24 : 147 ~ 174
[학술지(정기간행물)] - Willems, L. I / 2010 / Small molecule antagonists for chemokine CCR3 receptors / Med. Res. Rev 30 : 778 ~ 817
[학술지(정기간행물)] - Mori, Y / 2009 / Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor / J. Exp. Med 206 : 183 ~ 193
[학술지(정기간행물)] - Voehringer, D / 2007 / Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages / J. Leukoc. Biol 81 : 1434 ~ 1444
[학술지(정기간행물)] - Rothenberg, M. E / 2006 / The eosinophil / Annu. Rev. Immunol 24 : 147 ~ 174
[학술지(정기간행물)] - Willems, L. I / 2010 / Small molecule antagonists for chemokine CCR3 receptors / Med. Res. Rev 30 : 778 ~ 817
[학술지(정기간행물)] - Mori, Y / 2009 / Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor / J. Exp. Med 206 : 183 ~ 193
[학술지(정기간행물)] - Voehringer, D / 2007 / Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages / J. Leukoc. Biol 81 : 1434 ~ 1444
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UCI(KEPA) : I410-ECN-0101-2017-517-000870492