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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 276 - 281 (6page)
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Methylation events play a critical role in various cellular processes including regulation of gene transcription and proliferation. Recently, RUNX3 β-Smads signaling transduction pathway genes, showed strong tumor-suppressor activity by regulation of epithelial proliferation and apoptosis. To elucidate the potential etiological role of the RUNX3 gene in the development of hepato-cellular carcinoma (HCC), we have analyzed the methylation status of 5' CpG island of the RUNX3 gene in a series of 73 HCC tissues and 1 liver cell lines. Expectedly, promoter methylation of RUNX3 gene was found in 2 (2.7%) of 73 corresponding normal liver, whereas 30 (41.1%) of 73 HCCs and 4 (40%) of 10 liver cancer cell lines showed hypermethylation of the gene, respectively. There was no significant difference between promoter hypermethylaion and clinicopathologic parameters of primary HCC sam-ples, including histologic grade, microvascular invasion, and clinical stage. Interestingly, demethy-lating agent 5-aza-2-deoxycytidine induced reacti-vation and more potent expression of RUNX3 gene in HCC cell lines. Our findings indicate that promoter hypermethylation of RUNX3 gene may occur as an early event in the development of HCC and that methylation may be a major mechanism for inactivation of RUNX3 gene in HCC.
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참고문헌 (25)
참고문헌 신청
/ / Chiba T. Frequentloss of RUNX3 gene expression in human bile duct andpancreatic cancer cell lines. Oncogene 2004 : 2401 ~ 7
/ / Choi JK. Tumor suppressor activity of RUNX3. Oncogene2004 : 4336 ~ 40
/ / Derynck R. Transcriptional regulation of the transforminggrowth factor-beta-inducible mouse germ line Igalpha constant region gene by functional corporation ofSmad : 169
/ / Hagiwara K. Mutational analysis of the Smad6and Smad7 genes in hepatocellular carcinoma. Int J MolMed 2001 take (shita s) : 49 ~ 52
/ / Heldin C. Mechanisms ofTGF-beta signaling in regulation of cell growth anddifferentiation. Immunol Lett 2002 : 85 ~ 91
/ / Choi JK. Tumor suppressor activity of RUNX3. Oncogene2004 : 4336 ~ 40
/ / Derynck R. Transcriptional regulation of the transforminggrowth factor-beta-inducible mouse germ line Igalpha constant region gene by functional corporation ofSmad : 169
/ / Hagiwara K. Mutational analysis of the Smad6and Smad7 genes in hepatocellular carcinoma. Int J MolMed 2001 take (shita s) : 49 ~ 52
/ / Heldin C. Mechanisms ofTGF-beta signaling in regulation of cell growth anddifferentiation. Immunol Lett 2002 : 85 ~ 91
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