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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 583 - 588 (6page)
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RUNX1, a member of the runt domain gene family of transcription factors, encodes a heterodimeric transcription factor and regulates the expression of hematopoiesis and myeloid differentiation. RUNX1 has been one of the target genes for research into various autoimmune disea-ses due to its properties as a transcription factor and functional distribution for chromosomal trans-location. In an effort to identify additional gene polymorphisms in which variants have been implicated in asthma, we investigated the genetic polymorphisms in RUNX1 to evaluate it as a potential candidate gene for a host genetic study of asthma and IgE production. We identified 19 sequence variants by direct DNA sequencing in 24 individuals of which four common variants were selected for genotyping in our asthma cohort (1,055 asthmatic patients, 384 normal controls). Using logistic regression analysis for association with the risk of asthma, while controlling for age, gender, and smoking status as of asthma were detected. However, two poly-morphisms in the promoter region (-2084G＞ C and -1282G＞A) showed a marginal association with total IgE levels (0.03 and 0.03 in recessive models, respectively). Our findings suggest that poly-morphisms in RUNX1 might be one of the genetic factors for the regulation of IgE production
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참고문헌 (21)
참고문헌 신청
/ / Association of asthma with serum IgE levels and skin-test reactivity to allergens : 271 ~ 7
/ 1995 / Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia 23 : 2762 ~ 2769
/ 1995 / Positive and negative regulation of granulocyte macrophage colony stimulating factor promoter activity by AML1 related trans cription factor PEBP2 86 : 607 ~ 616
/ 1998 / Databases on transcriptional regulation TRANSFAC TRRD and COMPEL 26 : 362 ~ 367
/ 1999 / Allelic discrimination using fluorogenic probes and the 5nuclease assay 14 : 143 ~ 149
/ 1995 / Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia 23 : 2762 ~ 2769
/ 1995 / Positive and negative regulation of granulocyte macrophage colony stimulating factor promoter activity by AML1 related trans cription factor PEBP2 86 : 607 ~ 616
/ 1998 / Databases on transcriptional regulation TRANSFAC TRRD and COMPEL 26 : 362 ~ 367
/ 1999 / Allelic discrimination using fluorogenic probes and the 5nuclease assay 14 : 143 ~ 149
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The Roles of RUNX Family Proteins in Development of Immune Cells
Molecules and Cells
2020 .01
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CROX (Cluster Regulation of RUNX) as a Potential Novel Therapeutic Approach
Molecules and Cells
2020 .01
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Role of RUNX Family Transcription Factors in DNA Damage Response
Molecules and Cells
2020 .01
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Post-Translational Regulations of Transcriptional Activity of RUNX2
Molecules and Cells
2020 .01
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Oncogenic RUNX3: A Link between p53 Deficiency and MYC Dysregulation
Molecules and Cells
2020 .01
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Molecular Mechanism of Runx2-Dependent Bone Development
Molecules and Cells
2020 .01
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Single Nucleotide Polymorphisms Associated with Asthma
한국유전체학회 Conference
2003 .01
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RUNX1 Dosage in Development and Cancer
Molecules and Cells
2020 .01
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환경성 요인이 위암조직의 RUNX3 유전자 promoter 과메틸화에 미치는 영향
Korean Journal of Health Promotion
2008 .01
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Association between genetic variations of the transforming growth factor β receptor type III and asthma in a Korean population
Experimental and Molecular Medicine
2010 .01
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Association of the Human IL-28RA Gene Polymorphisms in a Korean Population with Asthma
Genomics & informatics
2006 .01
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Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis
Experimental and Molecular Medicine
2002 .01
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Osteoprotegerin is present on the membrane of osteoclasts isolated from mouse long bones
Experimental and Molecular Medicine
2002 .01
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The Clinical, Molecular, and Mechanistic Basis of RUNX1 Mutations Identified in Hematological Malignancies
Molecules and Cells
2020 .01
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Tour d’Horizon of Recent Advances in RUNX Family Gene Research
Molecules and Cells
2020 .01
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Hypermethylation of the RUNX3 gene in hepatocellular carcinoma
Experimental and Molecular Medicine
2005 .01
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The Role of RUNX1 in NF1-Related Tumors and Blood Disorders
Molecules and Cells
2020 .01
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Single Nucleotide Polymorphisms associated with Asthma Phenotypes
한국유전체학회 Conference
2002 .01
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Complex Interplay between the RUNX Transcription Factors and Wnt/β-Catenin Pathway in Cancer: A Tango in the Night
Molecules and Cells
2020 .01
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Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer
한국동물학회 학술대회
2002 .01
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