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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 641 - 652 (12page)
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The aim of this study was to identify molecular markers associated with oncogenic differentiation in hep-atocellular carcinoma (HCC). Using an unsupervised clustering method with a cDNA microarray, HCC (T) gene expression profiles and corresponding non-tu-tal 217 genes, 72 were expressed preferentialy in HCC tissues. Among 186 diferentialy regulated genes, there were molecular chaperone and tumor sup-pressor gene clusters in the Edmondson grades I and I (GI/I) subclass compared with the liver cirrhosis (LC) subclass. The Edmondson grades III and IV (GIII/IV) subclass with a poor survival (P = 0.0133) contained 122 diferentialy regulated genes with a cluster containing pared with the GI/II subclass. Imunohistochemical analysis revealed that ANXA2, one of the 72 genes pref-erentially expressed in HCC, was over-expressed in the sinusoidal endothelium and in malignant hepatocytes in HCC. The genes identified in the HCC subclasses wil be useful molecular markers for the genesis and pro-gresion of HCC. In addition, ANXA2 might be a novel marker for tumor angiogenesis in HCC.
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참고문헌 (25)
참고문헌 신청
/ / Hoofnagle JH. Elevations in serum alpha-fetoprotein levels in patients with chronic hepatitis B. Cancer 1989 : 2117 ~ 20
Alldinger I / 2005 / Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pan-creatic cancer 5 ( ) : 370 ~ 9
Awan A / 2002 / 5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis 290 : 1030 ~ 1036
Bontron S / 2002 / Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2 277 : 38847 ~ 38854
Buckbinder L / 1995 / Induction of the growth inhibitor IGF-binding protein 3 by p53 377 : 646 ~ 649
Alldinger I / 2005 / Gene expression analysis of pancreatic cell lines reveals genes overexpressed in pan-creatic cancer 5 ( ) : 370 ~ 9
Awan A / 2002 / 5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis 290 : 1030 ~ 1036
Bontron S / 2002 / Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2 277 : 38847 ~ 38854
Buckbinder L / 1995 / Induction of the growth inhibitor IGF-binding protein 3 by p53 377 : 646 ~ 649
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