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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 72 - 84 (13page)
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Several myeloid leukemia-derived cells have been reported to possess the ability to differentiate into dendritic cells (DC). MUTZ-3, a myeloid leukemia cell line, responds to GM-CSF, IL-4 and TNF-α, and acquires a phenotype similar to immature mono-cyte-derived DC (MoDC). In the present study, MUTZ-3-derived DC (MuDC) showed high level expression of HLA class II molecules, CD80 and CD86, and were able to function as potent antigen presenting cells as previously reported. Interes-tingly, MuDC maturation was induced by CD40- by LPS stimulation. We analyzed CCR1, CCR7 and Toll-like receptor (TLR) expressions in MuDC, and measured IL-10 and IL-12 production after maturation stimuli. Although MuDC expressed the mRNA for TLR4, a major component of the LPS receptor system, they did not show an enhanced level of CCR7 or cytokine production after LPS stimulation. In contrast, they responded to CD40 stimulation, which resulted in increased levels of CD83, CD86 and CCR7. Moreover, while LPS- stimulated MoDC could potently stimulate NK cells in a DC-NK cell co-culture, LPS-stimulated MuDC failed to stimulate primary NK cells. Taken together, our findings suggest that, although MuDC express TLR4, unlike TNF-α and IL-1βMuDC to acquire mature phenotypes, and they may have impaired activity to initiate innate immune response.
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참고문헌 (25)
참고문헌 신청
/ 1998 / Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice mutations in Tlr4 gene 282 : 2085 ~ 8
/ 1998 / The role of tumor necrosis factor alpha in modulating the quantity of peripheral blood-derived cytokine-driven human dendritic cells and its role in enhancing the qu
/ 1999 / Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopoly-saccharide evidence for TLR4 as the Lps gene product 162 : 3749 ~ 52
/ 1999 / Dendritic cells derived in vitro from acute myelogenous leukemia cells stimulate autologous,antileukemic T-cell responses. 93 : 780 ~ 6
/ 1999 / Human acute myeloblastic leukemia cells differ-entiate in vitro into mature dendritic cells and induce the differentiation of cytotoxic T cells against autologous le
/ 1998 / The role of tumor necrosis factor alpha in modulating the quantity of peripheral blood-derived cytokine-driven human dendritic cells and its role in enhancing the qu
/ 1999 / Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopoly-saccharide evidence for TLR4 as the Lps gene product 162 : 3749 ~ 52
/ 1999 / Dendritic cells derived in vitro from acute myelogenous leukemia cells stimulate autologous,antileukemic T-cell responses. 93 : 780 ~ 6
/ 1999 / Human acute myeloblastic leukemia cells differ-entiate in vitro into mature dendritic cells and induce the differentiation of cytotoxic T cells against autologous le
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