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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제10호
- 발행연도
- 2015.1
- 수록면
- 1,687 - 1,696 (10page)
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Supplementation with probiotics can protect against the development of food allergies by modulating the host immune response; however, the mechanisms are not fully understood. The objective of this study was to investigate the allergy-reducing effects of regulatory dendritic cells (regDCs) induced by Lactobacillus paracasei L9 (L9) in β-lactoglobulin (BLG)- sensitized mice. The L9 supplement suppressed the aberrant balance of Th1/Th2 responses to BLG in mice, via upregulation of the CD4+CD25+Foxp3+Treg cell responses. The amount of CD4+CD25+Foxp3+Treg cells in mesenteric lymph nodes increased by 51.85%. Furthermore, administration of L9 significantly induced the expression of CD103 and reduced the maturation status of DCs in mesenteric lymph nodes, Peyer’s patches, and spleen. Bone marrow-derived dendritic cells (BM-DCs) were activated by L9 in vitro, with an approximate 1.31-fold and 19.57-fold increase in expression of CD103 in CD11c+DCs and the level of IL-10 production, respectively, while the expression of CD86 did not change significantly. These data demonstrate that L9 reduced the BLG allergic sensitization, likely through regDCs mediated active suppression.
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참고문헌 (22)
참고문헌 신청
Adel-Patient K / 2000 / Evaluation of a high IgEresponder mouse model of allergy to bovine β-lactoglobulin (BLG): development of sandwich immunoassays for total and allergen
Akdis M / 2005 / Tregulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases / J. Allergy Clin. Immun 116 : 961 ~ 968
Akdis M / 2009 / Therapeutic manipulation of immune tolerance in allergic disease / Nat. Rev. Drug Discov 8 : 645 ~ 660
Berni CR / 2012 / The potential therapeutic efficacy of Lactobacillus GG in children with food allergies / Pharmaceuticals 5 : 655 ~ 664
Braun FC / 2011 / Can farm milk consumption prevent allergic diseases? / Clin. Exp. Allergy 41 : 29 ~ 35
Akdis M / 2005 / Tregulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases / J. Allergy Clin. Immun 116 : 961 ~ 968
Akdis M / 2009 / Therapeutic manipulation of immune tolerance in allergic disease / Nat. Rev. Drug Discov 8 : 645 ~ 660
Berni CR / 2012 / The potential therapeutic efficacy of Lactobacillus GG in children with food allergies / Pharmaceuticals 5 : 655 ~ 664
Braun FC / 2011 / Can farm milk consumption prevent allergic diseases? / Clin. Exp. Allergy 41 : 29 ~ 35
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