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Cancer cells and the immune system are closely related and thus influence each other. Although immune cells can suppress cancer cell growth, cancer cells can evade immune cell attack via immune escape mechanisms. Natural killer (NK) cells killcancer cells by secreting perforins and granzymes. Upon contact with cancer cells, NK cells form immune synapses to deliver the lethal hit. Mature NK cells are differentiated from hematopoietic stem cells in the bone marrow. They move to lymph nodes, where they are activated through interactions with dendritic cells. Interleukin-15 (IL-15) is a key molecule that activates mature NK cells. The adoptive transfer of NK cells to treat incurable cancer is an attractive approach. A certain number of activated NK cells are required for adoptive NK cell therapy. To prepare these NK cells, mature NK cells can be amplified to obtain sufficient numbers of NK cells. Alternatively, NK cells can be differentiated and amplified from hematopoietic stem cells. In addition, the selection of donors is important to achieve maximal efficacy. In this review, we discuss the overall procedures and strategies of NK cell therapy against cancer.
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참고문헌 (28)
참고문헌 신청
Cao X / 2007 / Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance / Immunity 27 : 635 ~ 646
Colucci F / 2003 / What does it take to make a natural killer? / Nat Rev Immunol 3 : 413 ~ 425
Cooper MA / 2009 / Cytokine-induced memory-like natural killer cells / Proc Natl Acad Sci USA 106 : 1915 ~ 1919
Davis DM / 1999 / The human natural killer cell immune synapse / Proc Natl Acad Sci USA 96 : 15062 ~ 15067
Fehniger TA / 2001 / Interleukin 15 : biology and relevance to human disease / Blood 97 : 14 ~ 32
Colucci F / 2003 / What does it take to make a natural killer? / Nat Rev Immunol 3 : 413 ~ 425
Cooper MA / 2009 / Cytokine-induced memory-like natural killer cells / Proc Natl Acad Sci USA 106 : 1915 ~ 1919
Davis DM / 1999 / The human natural killer cell immune synapse / Proc Natl Acad Sci USA 96 : 15062 ~ 15067
Fehniger TA / 2001 / Interleukin 15 : biology and relevance to human disease / Blood 97 : 14 ~ 32
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